POS0731 IDENTIFICATION OF AUTOANTIBODY SIGNATURES AND BIOMARKERS OF DISEASE ACTIVITY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) USING HIGH-THROUGHPUT PROTEOMIC MICROARRAYS

• Published in: Annals of the rheumatic diseases Vol. 83; no. Suppl 1; pp. 997 - 998
• Main Authors: Mak, A., Nasir, N., Cho, J.
• Format: Journal Article
• Language: English
• Published: Kidlington BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.2024; Elsevier B.V; Elsevier Limited
• Subjects: Adaptor proteins; Amino acid sequence; Apoptosis; Autoantibodies; Autoantigens; Bcl-10 protein; Bioinformatics; Biomarkers, Protein microarrays; Caspase; Cell differentiation; Cell signaling; Deoxyribonucleic acid; DNA; DNA microarrays; Gene expression; Kinases; Leukocyte migration; Lupus; Lymphocytes B; MAP kinase; Neural coding; Nucleotide sequence; omics; Pattern recognition receptors; Protein structure; Proteins; Risk assessment; Scientific Abstracts; Systemic lupus erythematosus; Vasculitis; Zinc finger proteins; omics; Biomarkers, Protein microarrays; Autoantibodies

Background:High-throughput protein microarrays are increasingly employed to investigate disease-related autoantibodies in patients with SLE for identification of novel serum autoantibodies and their signatures that correlate with and potentially predict disease activity, flare and damage in SLE. Her...