FRI0034 Rage Activity Influences Co-Development of Joint and Vascular Disease in RA

• Published in: Annals of the rheumatic diseases Vol. 75; no. Suppl 2; p. 438
• Main Authors: Yu, S., Wong, C.-K., Li, E.K., Tam, L.-S.
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.06.2016

BackgroundRAGE is expressed by many cells in blood and joints of RA and interacts with a variety of pro-inflammatory ligands, especially HMGB1 that are enriched in inflamed joint. The RAGE-ligand interaction leads to a sustained inflammatory response. Soluble RAGE (sRAGE) lacks the transmembrane and...