FRI0063 Non- Neutralizing Autoantibody Against GM-CSF in Connective Tissue Diseases and its Association with Pulmonary Involvements

• Published in: Annals of the rheumatic diseases Vol. 74; no. Suppl 2; p. 442
• Main Authors: Nagasawa, J., Kurasawa, K., Tanaka, A., Yamazaki, R., Okada, H., Arai, S., Owada, T., Maezawa, R.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Limited 01.06.2015

BackgroundGranulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic growth factor, particularly for differentiation of alveolar macrophage, and immune modulator including inflammation. Neutralizing autoantibodies against GM-CSF antibodies cause pulmonary alveolar protei...