Development of in vitro models of invasion for the pharmacological investigation of small molecule inhibitors of tumour progression : development and validation of a 3-dimensional tumour spheroid invasion model to evaluate the pharmacological effects of novel small molecule β3 integrin antagonists

• Main Author: Zraikat, Manar Saleh Ali
• Format: Dissertation
• Language: English
• Published: University of Bradford 2015
• Subjects: Cancer; Drug screening; Integrins; Invasion; Metastasis; Migration; Pharmacology; Spheroids; Transwells

Tumour dissemination is a major reason for failure of therapy for many tumour types therefore there is a requirement for novel targets & therapies. The αIIbβ3 and αvβ3 integrins have been demonstrated to have significant involvement at many stages of the tumour dissemination process including, t...