BS20 Macrophage-specific deletion of neuropilin-2 inhibits inflammatory signalling and attenuates atherosclerotic plaque development in apoe-deficient mice

• Published in: Heart (British Cardiac Society) Vol. 109; no. Suppl 3; p. A260
• Main Authors: Pellet-Many, Caroline, Fernando-Sayers, Jacob, Zachary, Ian
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Cardiovascular Society 02.06.2023; BMJ Publishing Group LTD
• Subjects: Atherosclerosis; Basic Science; Bone marrow; Kinases; Macrophage; Neuropilin

IntroductionAtherosclerosis is a multifaceted vascular disease involving several cell types and characterised by arterial wall inflammation resulting from the subendothelial retention, and modification, of lipoproteins by macrophages. Macrophages are highly plastic cells that can alter their phenoty...