253 PFS of elderly ovarian cancer patients might be predicted by G-8 geriatric screening tool – results of a retrospective cohort study

• Published in: International journal of gynecological cancer Vol. 31; no. Suppl 3; pp. A215 - A216
• Main Authors: Anic, K, Birkert, S, Schwab, R, Schmidt, MW, Linz, V, Krajnak, S, Heimes, A-S, Schmidt, M, Westphalen, C, Hartmann, EK, Hasenburg, A, Battista, M
• Format: Journal Article
• Language: English
• Published: Oxford BMJ Publishing Group Ltd 12.10.2021; BMJ Publishing Group LTD
• Subjects: Cohort analysis; Dementia; Food; Frailty; Geriatrics; Medical prognosis; Ovarian cancer
• DOI: 10.1136/ijgc-2021-ESGO.368
• ISSN: 1048-891X

Introduction/Background*The aim of this study was to evaluate the impact of the preoperative global health status on the prognosis of patients with ovarian cancer (OC) older than 60 years, who received cytoreductive surgery.MethodologyG-8 geriatric screening tool (G-8 score), Lee Schonberg prognostic index, Eastern Cooperative Oncology Group (ECOG) performance status and Charlson Comorbidity Index (CCI) were determined retrospectively in a consecutive cohort of elderly patients with OC. Univariate and multivariate Cox regression analyses and Kaplan-Meier method were performed to analyze the impact of the preoperative global health status on survival.Result(s)*116 patients entered the study. In multivariate analysis adjusted for clinical-pathological factors, only the G-8 score retained significance as a prognostic parameter of PFS (HR: 2.009; 95%-CI [1.091-3.699]. 56 patients were classified as G-8 non-frail with an increased PFS compared to 50 G-8 frail patients (53.4% vs. 16.7%; p=0.010). A higher CCI was associated with decreased PFS (45.1% vs. 22.2%; p=0.012) but it did not influence the risk of recurrences or death (p=0.360; p=0.111, respectively). The Lee Schonberg prognostic index, the ECOG and mean age were not associated with survival.Abstract 253 Table 1G-8 geriatric screening tool Category Items Possible responses (score) {1} Nutritional status Has food intake declined over the past three months due to loss of appetite, digestive problems, chewing, or swallowing difficulties? 0: severe decrease in food intake 1: moderate decrease in food intake 2: no decrease in food intake {2} Body-Mass-Index (BMI) [kg/m²]? 0: BMI <19 1: BMI between 19-21 2: BMI between 21-23 3: BMI ≥ 23 {3} Weight loss during the last three months? 0: weight loss >3 kg 1: unknown 2: weight loss between 1 and 3 kg 3: no weight loss {4} Functional status Mobility? 0: bed or chair bound 1: able to get out of bed/chair but does not go out 2: goes out {5} Cognitive- status Neuropsychological problems? 0: severe dementia/depression 1: mild dementia/depression 2: no psychological problems {6} Comorbidities Takes more than three prescription drugs per day? 0: yes 1: no {7} In comparison with other people of the same age, how does the patient consider his/her health status 0: not as good 0,5: does not know 1: as good 2: better {8} Age? 0: >85 years 1: 80 - ≤85 years 2: <80 years Conclusion*The G-8 score independently predicted PFS in elderly OC patients regardless of maximal surgical effort. Thus, it could be useful to assess surgical treatment based on frailty rather than age alone.