Regulation of human endothelial ICAM-1, E-selectin and VCAM-1 by polyunsaturated fatty acids and antioxidants

• Main Author: Collie-Duguid, Elaina S. R
• Format: Dissertation
• Language: English
• Published: University of Aberdeen 1997
• Subjects: Atherosclerosis; Endothelium; Heart disease

The 3 PUFA, EPA and DHA, down-regulated human endothelial adhesion molecules in the presence of an inflammatory stimulus, DHA exerted more pronounced effects than EPA. The 6 PUFA, in contrast, exerted limited control over endothelial adhesion molecule expression under the conditions employed in this...