Divergent evolution of a protein-protein interaction revealed through ancestral sequence reconstruction and resurrection

• Published in: bioRxiv
• Main Authors: Laursen, Louise, Calyseva, Jelena, Gibson, Toby, Jemth, Per
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 29.03.2020; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Affinity; Dendritic spines; Divergence; Evolution; Molecular Biology; Postsynaptic density; Protein interaction; Proteins; Receptor mechanisms

The postsynaptic density extends across the postsynaptic dendritic spine with Discs large (DLG) as the most abundant scaffolding protein. DLG dynamically alters the structure of the postsynaptic density, thus controlling the function and distribution of specific receptors at the synapse. PDZ domains...