Targeted LNPs deliver mRNA encoding IL-15 superagonists to balance efficacy and toxicity in cancer therapy

• Published in: bioRxiv
• Main Authors: Yu, Juntao, Li, Qian, Luo, Shenggen, Wang, Xiaona, Cheng, Qiang, Hu, Rongkuan
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 12.01.2024; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Adaptive immunity; Antitumor agents; Bioengineering; Cancer therapies; Intellectual property; Interleukin 15; Metastases; mRNA; Nanoparticles; Toxicity; Tumors

Interleukin-15 (IL-15) emerges as a promising immunotherapeutic candidate in oncology because of its pivotal role in modulating both innate and adaptive immunity. However, the therapeutic utility remains concern due to the unexpected toxicity. We propose here that the mRNA lipid nanoparticle (mRNA-L...