Enhanced expression of Dystrophin, IGF-1, CD44 and MYH3 in plasma and skeletal muscles including Diaphragm of mdx mice after oral administration of Neu REFIX Beta 1,3-1,6 glucan

• Published in: bioRxiv
• Main Authors: Senthilkumar Preethy, Sakamoto, Shuji, Higuchi, Takuma, Ichiyama, Koji, Yamamoto, Naoki, Ikewaki, Nobunao, Iwasaki, Masaru, Vidyasagar Devaprasad Dedeepiya, Subramaniam Srinivasan, Rajmohan, Mathaiyan, Senthilkumar, Rajappa, Abraham, Samuel Jk
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 27.02.2025; Cold Spring Harbor Laboratory
• Edition: 1.2
• Subjects: CD44 antigen; Diaphragm; Duchenne's muscular dystrophy; Dystrophin; Enzyme-linked immunosorbent assay; Genetic disorders; Genetics; Glucans; Immunohistochemistry; Insulin-like growth factor I; Insulin-like growth factors; Oral administration; Plasma; Skeletal muscle; Japan; β-glucan; MYH3; mice; Duchenne Muscular Dystrophy (DMD); CD44

Introduction: Duchenne muscular dystrophy (DMD) is a rare genetic disease, causing muscle degeneration due to lack of dystrophin with inadequate muscle regeneration culminating in muscle dysfunction. The N-163 strain of Aureobasidium Pullulans produced Beta-1,3-1,6-glucan (Neu REFIX) reported to be...