proovframe: frameshift-correction for long-read (meta)genomics

• Published in: bioRxiv
• Main Authors: Hackl, Thomas, Trigodet, Florian, Eren, A Murat, Biller, Steven J, Eppley, John M, Luo, Elaine, Burger, Andrew, Delong, Edward F, Fischer, Matthias G
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 24.08.2021; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Bioinformatics; Genomic analysis; Proteins

Long-read sequencing technologies hold big promises for the genomic analysis of complex samples such as microbial communities. Yet, despite improving accuracy, basic gene prediction on long-read data is still often impaired by frameshifts resulting from small indels. Consensus polishing using either...