ER sensing of lipid metabolism drives PRA family-dependent regulation of COPII vesicle transport

• Published in: bioRxiv
• Main Authors: Nakazato, Mitsuki, Nakamura, Hiroki, Kato, Mei, Ikema, Ryoko, Iguchi, Mizuki, Hanaoka, Kazuki, Eto, Katsuki, Karashima, Takefumi, Ikeda, Atsuko, Yabuki, Yukari, Schlarmann, Philipp, Manzano-Lopez, Javier, Aguilera-Romero, Auxiliadora, Sabido-Bozo, Susana, Perez-Linero, Ana Maria, Kana, Muneyoshi, Iefuji, Haruyuki, Riezman, Isabelle, Riezman, Howard, Muniz, Manuel, Funato, Kouichi
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.11.2024; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Cell Biology; Endoplasmic reticulum; Environmental stress; Golgi apparatus; Lipid composition; Lipid metabolism; Membrane trafficking; Phosphatidic acid; Protein transport; Yip3; COPII-mediated trafficking; Opi1; Membrane lipid; Ino2/Ino4 transcriptional activator

Newly synthesized secretory proteins and many lipids are transported from the endoplasmic reticulum (ER) to the Golgi prior to their ultimate destinations. The ER-to-Golgi transport must be tightly regulated during adaptation to environmental stress. However, the sensing mechanism and regulatory pat...