Translational adaptation of human viruses to the tissues they infect
Viruses need to hijack the translational machinery of the host cell for a productive infection to happen. However, given the dynamic landscape of tRNA pools among tissues, it is unclear whether different viruses infecting different tissues have adapted their codon usage toward their tropism. Here, w...
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07.04.2020
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| Abstract | Viruses need to hijack the translational machinery of the host cell for a productive infection to happen. However, given the dynamic landscape of tRNA pools among tissues, it is unclear whether different viruses infecting different tissues have adapted their codon usage toward their tropism. Here, we collect the coding sequences of over 500 human-infecting viruses and determine that tropism explains changes in codon usage. Using an in silico model of translational efficiency, we validate the correspondence of the viral codon usage with the translational machinery of their tropism. In particular, we propose that the improved translational adaptation to the upper respiratory airways of the pandemic agent SARS-CoV-2 coronavirus could enhance its transmissibility. Furthermore, this correspondence is specifically defined in early viral proteins, as upon infection cells undergo reprogramming of tRNA pools that favors the translation of late counterparts. |
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| AbstractList | Viruses need to hijack the translational machinery of the host cell for a productive infection to happen. However, given the dynamic landscape of tRNA pools among tissues, it is unclear whether different viruses infecting different tissues have adapted their codon usage toward their tropism. Here, we collect the coding sequences of over 500 human-infecting viruses and determine that tropism explains changes in codon usage. Using an in silico model of translational efficiency, we validate the correspondence of the viral codon usage with the translational machinery of their tropism. In particular, we propose that the improved translational adaptation to the upper respiratory airways of the pandemic agent SARS-CoV-2 coronavirus could enhance its transmissibility. Furthermore, this correspondence is specifically defined in early viral proteins, as upon infection cells undergo reprogramming of tRNA pools that favors the translation of late counterparts. |
| Author | Hernandez-Alias, Xavier Serrano, Luis Schaefer, Martin |
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| Cites_doi | 10.1101/2020.02.27.969006 10.1101/2020.02.22.20026500 10.1021/acschemneuro.0c00122 10.1101/2020.03.14.988345 10.1038/s41559-020-1124-7 10.1016/j.meegid.2020.104181 10.1101/2020.01.30.927806 10.1101/2020.01.26.919985 10.1038/s41591-020-0820-9 |
| ContentType | Paper |
| Copyright | 2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (“the License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020, Posted by Cold Spring Harbor Laboratory |
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| DOI | 10.1101/2020.04.06.027557 |
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| Keywords | SARS-CoV-2 tRNA tropism translation coronavirus tissue codon usage |
| Language | English |
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| Title | Translational adaptation of human viruses to the tissues they infect |
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