Evidences for functional trans-acting eRNA-promoter R-loops at Alu sequences

• Published in: bioRxiv
• Main Authors: Bai, Xue, Li, Feifei, Zhang, Zhihua
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 18.02.2021; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Alu elements; Bioinformatics; Coevolution; Deoxyribonucleic acid; DNA; Enhancers; Gene expression; Gene regulation; Hybrids; Nucleotide sequence; Promoters; R-loops; Ribonucleic acid; RNA; RNA-binding protein; Transcription factors; Alu; R-loop; enhancer-promoter-interaction; eRNA

Abstract Enhancers modulate gene expression by interacting with promoters. Models of enhancer-promoter interactions (EPIs) in the literature involve the activity of many components, including transcription factors and nucleic acid. However, the role that sequence similarity plays in EPIs, remains la...