Computational genomic discovery of diverse gene clusters harboring Fe-S flavoenzymes in anaerobic gut microbiota

• Published in: bioRxiv
• Main Authors: Victoria Pascal Andreu, Fischbach, Michael A, Medema, Marnix H
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 06.03.2020; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Bile; Bile acids; Bioinformatics; Cholic acid; Computer applications; Deoxycholic acid; Enzymes; Food sources; Gene clusters; Genomic analysis; Intestinal microflora; Lipids; Metabolism; Microbiota

The gut contains an enormous diversity of simple as well as complex molecules from highly diverse food sources as well as host-secreted molecules. This presents a large metabolic opportunity for the gut microbiota, but little is known on how gut microbes are able to catabolize this large chemical di...