Parkinson's Disease-Associated, Sex-specific Changes in DNA Methylation at PARK7 (DJ-1), ATXN1, SLC17A6, NR4A2, and PTPRN2 in Cortical Neurons

• Published in: bioRxiv
• Main Authors: Kochmanski, Joseph, Kuhn, Nathan C, Bernstein, Alison I
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 09.09.2021; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Aging; Cortex (parietal); Deoxyribonucleic acid; DNA; DNA methylation; Environmental factors; Epigenetics; Genomes; Movement disorders; Neurodegenerative diseases; Neuroscience; Nuclear receptors; Nurr1 protein; PARK7 protein; Parkinson's disease; Parkinsons disease; Sex differences

Evidence for epigenetic regulation playing a role in Parkinson's disease (PD) is growing, particularly for DNA modifications. Approximately 90% of PD cases are due to a complex interaction between age, genes, and environmental factors, and epigenetic marks are thought to mediate the relationshi...