Hypersilencing of SRRM4 suppresses basal microexon inclusion and promotes tumor growth across cancers

• Published in: bioRxiv
• Main Authors: Head, Sarah A, Hernandez-Alias, Xavier, Jae-Seong, Yang, Beltran-Sastre, Violeta, Torres-Méndez, Antonio, Irimia, Manuel, Schaefer, Martin H, Serrano, Luis
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 24.03.2020; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Cancer; Cancer Biology; Cell proliferation; Computational neuroscience; Exons; Gene expression; Nucleotides; Splicing factors; Tumor cell lines; Tumors; Xenografts; SRRM4; cancer; alternative splicing; proliferation; TCGA; microexons

Abstract RNA splicing is widely dysregulated in cancer, frequently due to altered expression or activity of splicing factors. Microexons are extremely small exons (3-27 nucleotides long) that are highly evolutionarily conserved and play critical roles in promoting neuronal differentiation and develo...