Dynamic genetic adaptation of Bacteroides thetaiotaomicron murine gut colonization

• Published in: bioRxiv
• Main Authors: Zhang, Manjing, Kennedy, Megan, Deleon, Orlando, Bissell, Jacie, Trigodet, Florian, Lolans, Karen, Temelkova, Sara, Carroll, Katherine T, Fiebig, Aretha, Deutschbauer, Adam M, Sidebottom, Ashley M, Henry, Christopher S, Rice, Phoebe A, Bergelson, Joy, Chang, Eugene
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 24.02.2022; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Adaptation; Amino acids; Animal models; Bacteroides thetaiotaomicron; Biodegradation; Carbohydrate metabolism; Colonization; Germfree; Metabolomics; Microbiology; Microbiomes; Oligosaccharides; Polysaccharides; Raffinose; Transcriptomics

To understand how a bacterium ultimately succeeds or fails in adapting to a new environment, it is essential to assess the temporal dynamics of its fitness over the course of colonization. The mammalian gut, into which exogenous microorganisms are regularly introduced, represents a biologically and...