Development of a 3D bioprinted airway smooth muscle model for manipulating structure and measuring contraction

• Published in: bioRxiv
• Main Authors: Osagie, Jeffery O, Syeda, Sanjana S, Turner-Brannen, Emily, Guimond, Michelle, Parrenas, Lumiere C, Haroon, Ahsen, Imasuen, Philip, West, Adrian R
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 19.12.2022; Cold Spring Harbor Laboratory
• Edition: 1.2
• Subjects: Actin; Alginic acid; Collagen; Cytochalasin D; Extracellular matrix; Fibrinogen; Fibrosis; Lung diseases; Mechanical properties; Muscle contraction; Physiology; Potassium chloride; Respiratory tract; Smooth muscle; Tissue engineering; Webs; Relaxation; 3D bioprinting; Airway smooth muscle; Contraction; Mechanobiology

The contractile function of airway smooth muscle (ASM) is inextricably linked to its mechanical properties and interaction with the surrounding mechanical environment. As tissue engineering approaches become more commonplace for studying lung biology, the inability to replicate realistic mechanical...