Low-frequency vibrational modes in G-quadruplexes reveal the mechanical properties of nucleic acids

• Published in: bioRxiv
• Main Authors: González-Jiménez, Mario, Ramakrishnan, Gopakumar, Wynne, Klaas
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 18.03.2020; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Biophysics; Deoxyribonucleic acid; DNA; DNA structure; Gene expression; Mechanical properties; Spectroscopy; Spectrum analysis; Vibrations; Raman spectroscopy; Dynamics; Nucleic acids

Low-frequency vibrations play an essential role in biomolecular processes involving DNA such as gene expression, charge transfer, drug intercalation, and DNA-protein recognition. However, understanding of the vibrational basis of these mechanisms relies on theoretical models due to the lack of exper...