Personalized Perturbation Profiles Reveal Concordance between Autism Blood Transcriptome Datasets

• Published in: bioRxiv
• Main Authors: Laird, Jason, Maertens, Alexandra
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 25.01.2021; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Autism; Autophagy; Bioinformatics; Biomarkers; Correlation analysis; Datasets; DNA damage; Gene expression; Mitochondria; Molecular modelling; Phagocytosis; R-loops; Transcriptomes; Ubiquitination

Abstract The complex heterogeneity of Autism Spectrum Disorder (ASD) has made quantifying disease specific molecular changes a challenge. Blood based transcriptomic assays have been performed to isolate these molecular changes and provide biomarkers to aid in ASD diagnoses, etiological understanding...