Ribosome profiling reveals ribosome stalling on tryptophan codons upon oxidative stress in fission yeast

• Published in: bioRxiv
• Main Authors: Rubio, Angela, Ghosh, Sanjay, Mulleder, Michael, Ralser, Markus, Mata, Juan
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 24.04.2020; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Cellular stress response; Codons; DNA damage; Genomes; Heat shock; Heavy metals; MAP kinase; Molecular Biology; Osmotic shock; Oxidative stress; Ribosomes; Signal transduction; Translation; Translation elongation; Translation initiation; tRNA Trp; Tryptophan; Yeast

Modulation of translation is an essential response to stress conditions. We have investigated the translational programmes launched by the fission yeast Schizosaccharomyces pombe subject to five environmental stresses: oxidative stress, heavy metal, heat shock, osmotic shock and DNA damage. We also...