Joint effects of genes underlying a temperature specialization tradeoff in yeast

• Published in: bioRxiv
• Main Authors: Alzaben, Faisal, Chuong, Julie N, Abrams, Melanie B, Brem, Rachel B
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 19.03.2021; Cold Spring Harbor Laboratory
• Edition: 1.2
• Subjects: Epistasis; Evolutionary Biology; Evolutionary genetics; Genes; High temperature; Introduced species; Phenotypes; Proteins; Saccharomyces cerevisiae; Sibling species; Specialization; Temperature tolerance; Yeast

Abstract A central goal of evolutionary genetics is to understand, at the molecular level, how organisms adapt to their environments. Landmark work has characterized steric clashes between variants arising in a given protein as it evolves a new function. For many traits, any such single gene represe...