Expanding RNA editing toolkit using an IDR-based strategy

RNA base editors should ideally be free of immunogenicity, compact, efficient and specific, which has not been achieved for C>U editing. Here we first describe a compact C>U editor entirely of human origin, created by fusing the human C>U editing enzyme RESCUE-S to CIRTS, a tiny, human-orig...

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Bibliographic Details
Published inbioRxiv
Main Authors Di, Minghui, Lv, Junjun, Jing, Zhengyu, Dickinson, Bryan, Tian Chi
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 23.12.2023
Cold Spring Harbor Laboratory
Edition1.1
Subjects
Editing
Fusion protein
Histidine
Immunogenicity
Molecular Biology
RNA editing
Online AccessGet full text
ISSN2692-8205
2692-8205
DOI10.1101/2023.12.23.573192

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