Association of Structural Variation with Cardiometabolic Traits in Finns

• Published in: bioRxiv
• Main Authors: Chen, Lei, Abel, Haley J, Das, Indraniel, Larson, David E, Ganel, Liron, Kanchi, Krishna L, Regier, Allison A, Young, Erica P, Kang, Chul Joo, Scott, Alexandra J, Chiang, Colby, Wang, Xinxin, Lu, Shuangjia, Christ, Ryan, Service, Susan K, Charleston Wk Chiang, Havulinna, Aki S, Kuusisto, Johanna, Boehnke, Michael, Laakso, Markku, Palotie, Aarno, Ripatti, Samuli, Freimer, Nelson B, Locke, Adam E, Stitziel, Nathan O, Hall, Ira M
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 13.12.2020; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Alanine; Cholesterol; Copy number; Gene deletion; Gene mapping; Genetic factors; Genetics; Genomes; Genotypes; Pyruvic acid; Whole genome sequencing

Abstract The contribution of genome structural variation (SV) to quantitative traits associated with cardiometabolic diseases remains largely unknown. Here, we present the results of a study examining genetic association between SVs and cardiometabolic traits in the Finnish population. We used sensi...