Non-negative Independent Factor Analysis disentangles discrete and continuous sources of variation in scRNA-seq data

• Published in: bioRxiv
• Main Authors: Mao, Weiguang, Maziyar Baran Pouyan, Kostka, Dennis, Chikina, Maria
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 03.05.2021; Cold Spring Harbor Laboratory
• Edition: 1.2
• Subjects: Bioinformatics; Computer applications; Factor analysis; Immunotherapy; Lymphocytes T; Principal components analysis; Ribonucleic acid; RNA; Transcription

Single cell RNA sequencing (scRNA-seq) enables transcriptional profiling at the level of individual cells. With the emergence of high-throughput platforms datasets comprising tens of thousands or more cells have become routine, and the technology is having an impact across a wide range of biomedical...