LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer

• Published in: bioRxiv
• Main Authors: Donatella Delle Cave, Buonaiuto, Silvia, Mangini, Maria, Sainz, Bruno, Annalisa Di Domenico, Iavazzo, Tea Teresa, Andolfi, Gennaro, Carme Cortina Duran, Sevillano, Marta, Heeschen, Christopher, Colonna, Vincenza, Corona, Marco, Cucciardi, Antonio, Martina Di Guida, Batlle, Eduard, Annachiara De Luca, Lonardo, Enza
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 27.03.2022; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Activin; Cancer Biology; Cell self-renewal; Metastases; Metastasis; mRNA; Pancreatic cancer; Population studies; Signal transduction; Stem cells; Therapeutic targets; Transforming growth factor-b; Laminin γ2 (LAMC2); Tumor-initiating cells (TICs); Pancreatic ductal adenocarcinoma (PDAC); Vactosertib; TGF-β signaling

Tumor-initiating cells (TIC), also known as cancer stem cells, are considered a specific subpopulation of cells necessary for cancer initiation and metastasis. Here, we report a LAMC2-positive cell population, which is endowed with enhanced self-renewal capacity, and is sufficient for tumor initiati...