Epigenetics linking genotype and phenotype in development and evolution
Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this vol...
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| Main Authors | , |
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| Format | eBook |
| Language | English |
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Berkeley
University of California Press
2011
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| Edition | 1st ed. |
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| Abstract | Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced. |
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| AbstractList | Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced. Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only by understood in terms of interactions that arise above the level of the gene. <![CDATA[Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.]]> |
| Author | Hallgrímsson, Benedikt Hall, Brian K |
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| Editor | Brian k. Hall Benedikt Hallgrímsson |
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| Snippet | Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that... <![CDATA[Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental... |
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| SubjectTerms | Developmental genetics Ecology & Evolutionary Biology Epigenesis Evolution Evolutionary genetics Genetic regulation Genotype-environment interaction Life Sciences Phenotype SCIENCE |
| SubjectTermsDisplay | Evolution Life Sciences Science |
| Subtitle | linking genotype and phenotype in development and evolution |
| TableOfContents | Epigenetics: linking genotype and phenotype in development and evolution -- Contents -- Contributors -- 1. Introduction Benedikt Hallgrímsson and Brian K. Hall -- Part One: Historical and Philosophical Foundations -- 2. A Brief History of the Term and Concept Epigenetics Brian K. Hall -- 3. Heuristic Reductionism and the Relative Significance of Epigenetic Inheritance in Evolution James Griesemer -- Part Two: Approaches to Epigenetics -- 4. The Epigenetics of Genomic Imprinting: Core Epigenetic Processes are Conserved in Mammals, Insects, and Plants Lori A. McEachern and Vett Lloyd -- 5. Methylation Mapping in Humans Christoph Grunau -- 6. Asexuality and Epigenetic Variation Root Gorelick, Manfred Laubichler, and Rachel Massicotte -- 7. Epigenesis, Preformation, and the Humpty Dumpty Problem Ellen W. Larsen and Joel Atallah -- 8. A Principle of Developmental Inertia Alessandro Minelli -- Part Three: Epigenetics of Vertebrate Organ Development -- 9. The Role of Epigenetics in Nervous System Development Chris Kovach, Pierre Mattar, and Carol Schuurmans -- 10. Morphogenesis of Pigment Patterns: Experimental and Modeling Approaches Lennart Olsson -- 11. Epigenetic Interactions of the Cardiac Neural Crest Martha Alonzo, Kathleen K. Smith, and Margaret L. Kirby -- 12. Epigenetics in Bone and Cartilage Development Tamara A. Franz-Odendaal -- 13. Muscle-Bone Interactions and the Development of Skeletal Phenotype: Jaw Muscles and the Skull Susan W. Herring -- 14. Evolution of the Apical Ectoderm in the Developing Vertebrate Limb Lisa Noelle Cooper, Brooke Autumn Armfield, and J. G. M. Thewissen -- 15. Role of Skeletal Muscle in the Epigenetic Shaping of Organs, Tissues, and Cell Fate Choices Boris Kablar -- Part Four: Epigenetics in Evolution and Disease -- 16. Epigenetic Integration, Complexity, and Evolvability of the Head: Rethinking the Functional Matrix Hypothesis Daniel E. Lieberman -- 17. Epigenetic Interactions: The Developmental Route to Functional Integration Miriam Leah Zelditch and Donald L. Swiderski -- 18. Epigenetic Contributions to Adaptive Radiation: Insights from Threespine Stickleback Susan A. Foster and Matthew A. Wund -- 19. Learning, Developmental Plasticity, and the Rate of Morphological Evolution Christopher J. Neufeld and A. Richard Palmer -- 20. Epigenetics: Adaptation or Contingency? Thomas F. Hansen -- 21. The Epigenetics of Dysmorphology: Craniosynostosis as an Example Christopher J. Percival and Joan T. Richtsmeier -- 22. Epigenetics of Human Disease Peter D. Gluckman, Mark A. Hanson, Alan S. Beedle, Tatjana Buklijas, and Felicia M. Low -- 23. Epigenetics: The Context of Development Benedikt Hallgrímsson and Brian K. Hall -- Index. Front Matter Table of Contents CONTRIBUTORS 1: Introduction 2: A Brief History of the Term and concept Epigenetics 3: Heuristic Reductionism and the Relative Significance of Epigenetic Inheritance in Evolution 4: The Epigenetics of Genomic Imprinting: 5: Methylation Mapping in Humans 6: Asexuality and epigenetic variation 7: Epigenesis, Preformation, and the Humpty Dumpty Problem 8: A Principle of Developmental Inertia 9: The Role of Epigenetics in Nervous System Development 10: Morphogenesis of Pigment Patterns: 11: Epigenetic Interactions of the Cardiac Neural Crest 12: Epigenetics in Bone and Cartilage Development 13: Muscle–Bone Interactions and the Development of Skeletal Phenotype: 14: Evolution of the Apical Ectoderm in The Developing Vertebrate Limb 15: Role of Skeletal Muscle in the Epigenetic Shaping of Organs, Tissues, and Cell Fate Choices 16: Epigenetic Integration, Complexity, and Evolvability of the Head: 17: Epigenetic Interactions: 18: Epigenetic Contributions to Adaptive Radiation: 19: Learning, Developmental Plasticity, and the Rate of Morphological Evolution 20: Epigenetics: 21: The Epigenetics of Dysmorphology: 22: Epigenetics of Human Disease 23: Epigenetics: INDEX Back Matter Cover Title Page, Copyright Contents Contributors 1. Introduction Part I: Historical and Philosophical Foundations 2. A Brief History of the Term and Concept Epigenetics 3. Heuristic Reductionism and the Relative Significance of Epigenetic Inheritance in Evolution Part II: Approaches to Epigenetics 4. The Epigenetics of Genomic Imprinting: Core Epigenetic Processes Are Conserved in Mammals, Insects, and Plants 5. Methylation Mapping in Humans 6. Asexuality and Epigenetic Variation 7. Epigenesis, Preformation, and the Humpty Dumpty Problem 8. A Principle of Developmental Inertia Part III: Epigenetics of Vertebrate Organ Development 9. The Role of Epigenetics in Nervous System Development 10. Morphogenesis of Pigment Patterns: Experimental and Modeling Approaches 11. Epigenetic Interactions of the Cardiac Neural Crest 12. Epigenetics in Bone and Cartilage Development 13. Muscle–Bone Interactions and the Development of Skeletal Phenotype: Jaw Muscles and the Skull 14. Evolution of the Apical Ectoderm in the Developing Vertebrate Limb 15. Role of Skeletal Muscle in the Epigenetic Shaping of Organs, Tissues, and Cell Fate Choices Part IV: Epigenetics in Evolution and Disease 16. Epigenetic Integration, Complexity, and Evolvability of the Head: Rethinking the Functional Matrix Hypothesis 17. Epigenetic Interactions: The Developmental Route to Functional Integration 18. Epigenetic Contributions to Adaptive Radiation: Insights from ThreeSpine Stickleback 19. Learning, Developmental Plasticity, and the Rate of Morphological Evolution 20. Epigenetics: Adaptation or Contingency 21. The Epigenetics of Dysmorphology: Craniosynostosis as an Example 22. Epigenetics of Human Disease 23. Epigenetics: The Context of Development Index Production Notes 16 Epigenetic Integration, Complexity, and Evolvability of the Head: Rethinking The Functional Matrix Hypothesis -- Daniel E. Lieberman -- 17 Epigenetic Interactions: The Developmental Route to Functional Integration -- Miriam Leah Zelditch and Donald L. Swiderski -- 18 Epigenetic Contributions to Adaptive Radiation: Insights From Threespine Stickleback -- Susan A. Foster and Matthew A. Wund -- 19 Learning, Developmental Plasticity, and the Rate of Morphological Evolution -- Christopher J. Neufeld and A. Richard Palmer -- 20 Epigenetics: Adaptation or Contingency? -- Thomas F. Hansen -- 21 The Epigenetics of Dysmorphology: Craniosynostosis as an Example -- Christopher J. Percival and Joan T. Richtsmeier -- 22 Epigenetics of Human Disease -- Peter D. Gluckman, Mark A. Hanson, Alan S. Beedle, Tatjana Buklijas, and Felicia M. Low -- 23 Epigenetics: The Context of Development -- Benedikt Hallgrímsson and Brian K. Hall -- Index Cover -- Half title -- Title -- Copyright -- Contents -- Contributors -- 1 Introduction -- Benedikt Hallgrímsson and Brian K. Hall -- Part I Historical and Philosophical Foundations -- 2 A Brief History of the Term and Concept Epigenetics -- Brian K. Hall -- 3 Heuristic Reductionism and the Relative Significance of Epigenetic Inheritance in Evolution -- James Griesemer -- Part II Approaches to Epigenetics -- 4 The Epigenetics of Genomic Imprinting: Core Epigenetic Processes are Conserved in Mammals, Insects, and Plants -- Lori A. McEachern and Vett Lloyd -- 5 Methylation Mapping in Humans -- Christoph Grunau -- 6 Asexuality and Epigenetic Variation -- Root Gorelick, Manfred Laubichler, and Rachel Massicotte -- 7 Epigenesis, Preformation, and the Humpty Dumpty Problem -- Ellen W. Larsen and Joel Atallah -- 8 A Principle of Developmental Inertia -- Alessandro Minelli -- Part III Epigenetics of Vertebrate Organ Development -- 9 The Role of Epigenetics in Nervous System Development -- Chris Kovach, Pierre Mattar, and Carol Schuurmans -- 10 Morphogenesis of Pigment Patterns: Experimental and Modeling Approaches -- Lennart Olsson -- 11 Epigenetic Interactions of the Cardiac Neural Crest -- Martha Alonzo, Kathleen K. Smith, and Margaret L. Kirby -- 12 Epigenetics in Bone and Cartilage Development -- Tamara A. Franz-Odendaal -- 13 Muscle-Bone Interactions and the Development of Skeletal Phenotype: Jaw Muscles and the Skull -- Susan W. Herring -- 14 Evolution of the Apical Ectoderm in the Developing Vertebrate Limb -- Lisa Noelle Cooper, Brooke Autumn Armfield, and J. G. M. Thewissen -- 15 Role of Skeletal Muscle in the Epigenetic Shaping of Organs, Tissues, and Cell Fate Choices -- Boris Kablar -- Part IV Epigenetics in Evolution and Disease |
| Title | Epigenetics |
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