A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity

• Published in: Journal of Obesity Vol. 2015; no. 2015; pp. 246 - 252
• Main Authors: Adams, Ted D., Lewis, Tracey, Mao, Rong, Xin, Yuanpei, Hasstedt, Sandra J., Hunt, Steven C.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2015; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Wiley
• Subjects: ADP-Ribosylation Factors - genetics; Adult; Aged; Aged, 80 and over; Alleles; Analysis; Body Mass Index; Chromosomes; Chromosomes, Human, Pair 20; Colleges & universities; Comparative Genomic Hybridization; Copy number variations; Deoxyribonucleic acid; DNA; DNA Copy Number Variations; Drug dosages; Families & family life; Female; Genes; Genetic aspects; Genetic Pleiotropy; Genetic Predisposition to Disease; Genetic variation; Genetics; Genome-Wide Association Study; Genomes; Genomics; Genotype; Humans; Male; Medicine; Middle Aged; Obesity; Obesity, Morbid - genetics; Pedigree; Physiological aspects; Reference Values; Risk factors; Sequence Deletion; Software; Thinness - genetics; Young Adult; United States; Qatar

Background/Objectives. To identify copy number variants (CNVs) which are associated with body mass index (BMI). Subjects/Methods. CNVs were identified using array comparative genomic hybridization (aCGH) on members of pedigrees ascertained through severely obese (BMI ≥ 35 kg/m2) sib pairs (86 pedigr...