Development of the First Aliphatic 18F‑Labeled Tetrazine Suitable for Pretargeted PET ImagingExpanding the Bioorthogonal Tool Box

• Published in: Journal of medicinal chemistry Vol. 64; no. 20; pp. 15297 - 15312
• Main Authors: Battisti, Umberto M, Bratteby, Klas, Jørgensen, Jesper T, Hvass, Lars, Shalgunov, Vladimir, Mikula, Hannes, Kjær, Andreas, Herth, Matthias Manfred
• Format: Journal Article
• Language: English
• Published: American Chemical Society 28.10.2021

Pretargeted imaging of nanomedicines have attracted considerable interest because it has the potential to increase imaging contrast while reducing radiation burden to healthy tissue. Currently, the tetrazine ligation is the fastest bioorthogonal reaction for this strategy and, consequently, the stat...