Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease

• Published in: Parkinson's disease Vol. 2011; no. 2011; pp. 931 - 941
• Main Authors: Naveilhan, Philippe, Lescaudron, Laurent, Damier, Philippe, Anegon, Ignacio, Tesson, Laurent, Usal, Claire, Rémy, Séverine, Thinard, Reynald, Boyer, Cécile, Lelan, Faustine, Neveu, Isabelle
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2011; Hindawi Publishing Corporation; SAGE-Hindawi Access to Research; John Wiley & Sons, Inc; Wiley
• Subjects: Care and treatment; Cell proliferation; Diagnosis; Genetic aspects; Neurons; Parkinson's disease; Physiological aspects; France

A transgenic Sprague Dawley rat bearing the A30P and A53T α-synuclein (α-syn) human mutations under the control of the tyrosine hydroxylase promoter was generated in order to get a better understanding of the role of the human α-syn mutations on the neuropathological events involved in the progressi...