The inflammasome NLRs in immunity, inflammation, and associated diseases

• Published in: Annual review of immunology Vol. 29; p. 707
• Main Authors: Davis, Beckley K, Wen, Haitao, Ting, Jenny P-Y
• Format: Journal Article
• Language: English
• Published: United States 23.04.2011
• Subjects: Animals; Humans; Inflammasomes - immunology; Inflammation - immunology; Inflammation Mediators - immunology; Intercellular Signaling Peptides and Proteins - immunology; Metabolic Diseases - immunology; Neoplasms - immunology

Inflammasome activation leads to caspase-1 activation, which causes the maturation and secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup of the NLR (nucleotide-binding domain, leucine-rich repeat containing) proteins are key mediators of the inflammasome. Studies of gene-defici...