Leptin, Leptin Soluble Receptor, and the Free Leptin Index following a Diet and Physical Activity Lifestyle Intervention in Obese Males and Females

• Published in: Journal of Obesity Vol. 2016; no. 2016; pp. 413 - 417
• Main Authors: Herrick, Jeffrey E., Gollie, Jared M., Panza, Gino S.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2016; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Analysis; Body Mass Index; Diet, Reducing; Exercise; Female; Food and nutrition; Genetic aspects; Humans; Leptin; Leptin - metabolism; Male; Middle Aged; Obesity - blood; Obesity - diet therapy; Obesity - therapy; Overweight persons; Physiological aspects; Receptors, Leptin - metabolism; Treatment Outcome; United States

Leptin (LEP) is associated with appetite regulation and metabolism. Concentration is linear with adiposity, suggesting LEP resistance. LEP circulates freely and bound with its soluble receptor (sOB-r); the ratio is the free leptin index (FLI), an index of leptin resistance; lower FLI suggests reduce...