Leptin, Leptin Soluble Receptor, and the Free Leptin Index following a Diet and Physical Activity Lifestyle Intervention in Obese Males and Females

Leptin (LEP) is associated with appetite regulation and metabolism. Concentration is linear with adiposity, suggesting LEP resistance. LEP circulates freely and bound with its soluble receptor (sOB-r); the ratio is the free leptin index (FLI), an index of leptin resistance; lower FLI suggests reduce...

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Published inJournal of Obesity Vol. 2016; no. 2016; pp. 413 - 417
Main Authors Herrick, Jeffrey E., Gollie, Jared M., Panza, Gino S.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 01.01.2016
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Analysis
Body Mass Index
Diet, Reducing
Exercise
Female
Food and nutrition
Genetic aspects
Humans
Leptin
Leptin - metabolism
Male
Middle Aged
Obesity - blood
Obesity - diet therapy
Obesity - therapy
Overweight persons
Physiological aspects
Receptors, Leptin - metabolism
Treatment Outcome
United States
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Abstract Leptin (LEP) is associated with appetite regulation and metabolism. Concentration is linear with adiposity, suggesting LEP resistance. LEP circulates freely and bound with its soluble receptor (sOB-r); the ratio is the free leptin index (FLI), an index of leptin resistance; lower FLI suggests reduced biological action. Purpose. The aim was to determine the effect of changes in adipose tissue distribution on LEP, sOB-r, and FLI following 6 months (6 M) of a diet/exercise weight loss program (WLP). In addition, we aim to identify predictors of the FLI. Methods. 6 M WLP consisted of diet/lifestyle interventions following ADA guidelines. Body composition was assessed by DXA. LEP and sOB-r analysis were done via ELISA. Results. 10 adults completed the WLP. Significant reductions were seen in total fat percentage (% fat), nontrunk fat, (NTF), and trunk fat (TF) from base to 3 m and 6 M ( p ≤ 0.05 ). The FLI were reduced at 3 M and 6 M for males and 6 M for females. Total body fat and body weight predicted the FLI in both sexes. Conclusions. LEP and FLI reductions following 6 M of WLP were achieved independent of sOB-r changes. We also demonstrate that the FLI can be predicted noninvasively through total fat mass and body weight in kilograms.
AbstractList Leptin (LEP) is associated with appetite regulation and metabolism. Concentration is linear with adiposity, suggesting LEP resistance. LEP circulates freely and bound with its soluble receptor (sOB-r); the ratio is the free leptin index (FLI), an index of leptin resistance; lower FLI suggests reduced biological action. Purpose. The aim was to determine the effect of changes in adipose tissue distribution on LEP, sOB-r, and FLI following 6 months (6 M) of a diet/exercise weight loss program (WLP). In addition, we aim to identify predictors of the FLI. Methods. 6 M WLP consisted of diet/lifestyle interventions following ADA guidelines. Body composition was assessed by DXA. LEP and sOB-r analysis were done via ELISA. Results. 10 adults completed the WLP. Significant reductions were seen in total fat percentage (% fat), nontrunk fat, (NTF), and trunk fat (TF) from base to 3 m and 6 M ( p ≤ 0.05 ). The FLI were reduced at 3 M and 6 M for males and 6 M for females. Total body fat and body weight predicted the FLI in both sexes. Conclusions. LEP and FLI reductions following 6 M of WLP were achieved independent of sOB-r changes. We also demonstrate that the FLI can be predicted noninvasively through total fat mass and body weight in kilograms.
Leptin (LEP) is associated with appetite regulation and metabolism. Concentration is linear with adiposity, suggesting LEP resistance. LEP circulates freely and bound with its soluble receptor (sOB-r); the ratio is the free leptin index (FLI), an index of leptin resistance; lower FLI suggests reduced biological action. Purpose . The aim was to determine the effect of changes in adipose tissue distribution on LEP, sOB-r, and FLI following 6 months (6 M) of a diet/exercise weight loss program (WLP). In addition, we aim to identify predictors of the FLI. Methods . 6 M WLP consisted of diet/lifestyle interventions following ADA guidelines. Body composition was assessed by DXA. LEP and sOB-r analysis were done via ELISA. Results . 10 adults completed the WLP. Significant reductions were seen in total fat percentage (% fat), nontrunk fat, (NTF), and trunk fat (TF) from base to 3 m and 6 M ( p ≤ 0.05). The FLI were reduced at 3 M and 6 M for males and 6 M for females. Total body fat and body weight predicted the FLI in both sexes. Conclusions . LEP and FLI reductions following 6 M of WLP were achieved independent of sOB-r changes. We also demonstrate that the FLI can be predicted noninvasively through total fat mass and body weight in kilograms.
Leptin (LEP) is associated with appetite regulation and metabolism. Concentration is linear with adiposity, suggesting LEP resistance. LEP circulates freely and bound with its soluble receptor (sOB-r); the ratio is the free leptin index (FLI), an index of leptin resistance; lower FLI suggests reduced biological action. Purpose . The aim was to determine the effect of changes in adipose tissue distribution on LEP, sOB-r, and FLI following 6 months (6 M) of a diet/exercise weight loss program (WLP). In addition, we aim to identify predictors of the FLI. Methods . 6 M WLP consisted of diet/lifestyle interventions following ADA guidelines. Body composition was assessed by DXA. LEP and sOB-r analysis were done via ELISA. Results . 10 adults completed the WLP. Significant reductions were seen in total fat percentage (% fat), nontrunk fat, (NTF), and trunk fat (TF) from base to 3 m and 6 M ( p ≤ 0.05 ). The FLI were reduced at 3 M and 6 M for males and 6 M for females. Total body fat and body weight predicted the FLI in both sexes. Conclusions . LEP and FLI reductions following 6 M of WLP were achieved independent of sOB-r changes. We also demonstrate that the FLI can be predicted noninvasively through total fat mass and body weight in kilograms.
Leptin (LEP) is associated with appetite regulation and metabolism. Concentration is linear with adiposity, suggesting LEP resistance. LEP circulates freely and bound with its soluble receptor (sOB-r); the ratio is the free leptin index (FLI), an index of leptin resistance; lower FLI suggests reduced biological action. Purpose. The aim was to determine the effect of changes in adipose tissue distribution on LEP, sOB-r, and FLI following 6 months (6 M) of a diet/exercise weight loss program (WLP). In addition, we aim to identify predictors of the FLI. Methods. 6 M WLP consisted of diet/lifestyle interventions following ADA guidelines. Body composition was assessed by DXA. LEP and sOB-r analysis were done via ELISA. Results. 10 adults completed the WLP. Significant reductions were seen in total fat percentage (% fat), nontrunk fat, (NTF), and trunk fat (TF) from base to 3 m and 6 M (p [less than or equal to] 0.05). The FLI were reduced at 3 M and 6 M for males and 6 M for females. Total body fat and body weight predicted the FLI in both sexes. Conclusions. LEP and FLI reductions following 6M of WLP were achieved independent of sOB-r changes. We also demonstrate that the FLI can be predicted noninvasively through total fat mass and body weight in kilograms.
Leptin (LEP) is associated with appetite regulation and metabolism. Concentration is linear with adiposity, suggesting LEP resistance. LEP circulates freely and bound with its soluble receptor (sOB-r); the ratio is the free leptin index (FLI), an index of leptin resistance; lower FLI suggests reduced biological action. Purpose. The aim was to determine the effect of changes in adipose tissue distribution on LEP, sOB-r, and FLI following 6 months (6 M) of a diet/exercise weight loss program (WLP). In addition, we aim to identify predictors of the FLI. Methods. 6 M WLP consisted of diet/lifestyle interventions following ADA guidelines. Body composition was assessed by DXA. LEP and sOB-r analysis were done via ELISA. Results. 10 adults completed the WLP. Significant reductions were seen in total fat percentage (% fat), nontrunk fat, (NTF), and trunk fat (TF) from base to 3 m and 6 M ( p <= 0.05 ). The FLI were reduced at 3 M and 6 M for males and 6 M for females. Total body fat and body weight predicted the FLI in both sexes. Conclusions. LEP and FLI reductions following 6 M of WLP were achieved independent of sOB-r changes. We also demonstrate that the FLI can be predicted noninvasively through total fat mass and body weight in kilograms.
Leptin (LEP) is associated with appetite regulation and metabolism. Concentration is linear with adiposity, suggesting LEP resistance. LEP circulates freely and bound with its soluble receptor (sOB-r); the ratio is the free leptin index (FLI), an index of leptin resistance; lower FLI suggests reduced biological action. . The aim was to determine the effect of changes in adipose tissue distribution on LEP, sOB-r, and FLI following 6 months (6 M) of a diet/exercise weight loss program (WLP). In addition, we aim to identify predictors of the FLI. . 6 M WLP consisted of diet/lifestyle interventions following ADA guidelines. Body composition was assessed by DXA. LEP and sOB-r analysis were done via ELISA. . 10 adults completed the WLP. Significant reductions were seen in total fat percentage (% fat), nontrunk fat, (NTF), and trunk fat (TF) from base to 3 m and 6 M ( ≤ 0.05). The FLI were reduced at 3 M and 6 M for males and 6 M for females. Total body fat and body weight predicted the FLI in both sexes. . LEP and FLI reductions following 6 M of WLP were achieved independent of sOB-r changes. We also demonstrate that the FLI can be predicted noninvasively through total fat mass and body weight in kilograms.
Leptin (LEP) is associated with appetite regulation and metabolism. Concentration is linear with adiposity, suggesting LEP resistance. LEP circulates freely and bound with its soluble receptor (sOB-r); the ratio is the free leptin index (FLI), an index of leptin resistance; lower FLI suggests reduced biological action. Purpose. The aim was to determine the effect of changes in adipose tissue distribution on LEP, sOB-r, and FLI following 6 months (6 M) of a diet/exercise weight loss program (WLP). In addition, we aim to identify predictors of the FLI. Methods. 6 M WLP consisted of diet/lifestyle interventions following ADA guidelines. Body composition was assessed by DXA. LEP and sOB-r analysis were done via ELISA. Results. 10 adults completed the WLP. Significant reductions were seen in total fat percentage (% fat), nontrunk fat, (NTF), and trunk fat (TF) from base to 3 m and 6 M (p≤0.05). The FLI were reduced at 3 M and 6 M for males and 6 M for females. Total body fat and body weight predicted the FLI in both sexes. Conclusions. LEP and FLI reductions following 6 M of WLP were achieved independent of sOB-r changes. We also demonstrate that the FLI can be predicted noninvasively through total fat mass and body weight in kilograms.
Audience Academic
Author Herrick, Jeffrey E.
Gollie, Jared M.
Panza, Gino S.
AuthorAffiliation Department of Rehabilitation Science, George Mason University, 4400 University Drive, MS 2G7, Fairfax, VA 22030, USA
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/28050279$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1093/ajcn/71.4.901
10.1053/meta.2000.6258
10.1210/jc.87.4.1708
10.1371/journal.pone.0034787
10.1677/joe-07-0569
10.1530/eje.1.02288
10.1038/oby.2002.81
10.1038/sj/ijo/0801951
10.1111/j.1365-2265.2005.02195.x
10.1385/ENDO:14:3:429
10.1111/j.1365-2265.2004.02101.x
10.1152/ajpendo.2000.279.2.E307
10.1038/oby.2003.144
10.2337/diabetes.51.7.2105
10.1016/j.jacc.2008.05.060
10.1007/s001250050804
10.1210/jc.2002-021604
10.1007/s001250051326
10.1186/1465-9921-11-152
10.7326/0003-4819-130-8-199904200-00014
10.1172/jci200317490
10.1016/j.peptides.2014.03.015
10.4049/jimmunol.174.6.3137
10.1172/jci118913
10.1055/s-0030-1253422
10.1210/jc.82.2.561
ContentType Journal Article
Copyright Copyright © 2016 Jeffrey E. Herrick et al.
COPYRIGHT 2016 John Wiley & Sons, Inc.
Copyright © 2016 Jeffrey E. Herrick et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2016 Jeffrey E. Herrick et al. 2016
Copyright_xml – notice: Copyright © 2016 Jeffrey E. Herrick et al.
– notice: COPYRIGHT 2016 John Wiley & Sons, Inc.
– notice: Copyright © 2016 Jeffrey E. Herrick et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2016 Jeffrey E. Herrick et al. 2016
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References 22
23
24
26
28
(18) 2000; 279
(32) 2000; 71
30
31
10
11
12
14
15
16
(27) 2010; 31
19
1
2
3
4
5
6
7
8
9
20
21
References_xml – volume: 71
  start-page: 901
  issue: 4
  year: 2000
  ident: 32
  publication-title: American Journal of Clinical Nutrition
  doi: 10.1093/ajcn/71.4.901
– ident: 31
  doi: 10.1053/meta.2000.6258
– ident: 21
  doi: 10.1210/jc.87.4.1708
– ident: 9
  doi: 10.1371/journal.pone.0034787
– ident: 7
  doi: 10.1677/joe-07-0569
– ident: 22
  doi: 10.1530/eje.1.02288
– ident: 19
  doi: 10.1038/oby.2002.81
– ident: 28
  doi: 10.1038/sj/ijo/0801951
– ident: 14
  doi: 10.1111/j.1365-2265.2005.02195.x
– ident: 15
  doi: 10.1385/ENDO:14:3:429
– ident: 20
  doi: 10.1111/j.1365-2265.2004.02101.x
– volume: 279
  start-page: E307
  issue: 2
  year: 2000
  ident: 18
  publication-title: American Journal of Physiology—Endocrinology and Metabolism
  doi: 10.1152/ajpendo.2000.279.2.E307
– ident: 16
  doi: 10.1038/oby.2003.144
– ident: 10
  doi: 10.2337/diabetes.51.7.2105
– ident: 12
  doi: 10.1016/j.jacc.2008.05.060
– volume: 31
  start-page: 679
  issue: 5
  year: 2010
  ident: 27
  publication-title: Neuroendocrinology Letters
– ident: 24
  doi: 10.1007/s001250050804
– ident: 2
  doi: 10.1210/jc.2002-021604
– ident: 6
  doi: 10.1007/s001250051326
– ident: 26
  doi: 10.1186/1465-9921-11-152
– ident: 5
  doi: 10.7326/0003-4819-130-8-199904200-00014
– ident: 1
  doi: 10.1172/jci200317490
– ident: 23
  doi: 10.1016/j.peptides.2014.03.015
– ident: 3
  doi: 10.4049/jimmunol.174.6.3137
– ident: 4
  doi: 10.1186/1465-9921-11-152
– ident: 8
  doi: 10.1172/jci118913
– ident: 11
  doi: 10.1055/s-0030-1253422
– ident: 30
  doi: 10.1210/jc.82.2.561
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Snippet Leptin (LEP) is associated with appetite regulation and metabolism. Concentration is linear with adiposity, suggesting LEP resistance. LEP circulates freely...
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SubjectTerms Analysis
Body Mass Index
Diet, Reducing
Exercise
Female
Food and nutrition
Genetic aspects
Humans
Leptin
Leptin - metabolism
Male
Middle Aged
Obesity - blood
Obesity - diet therapy
Obesity - therapy
Overweight persons
Physiological aspects
Receptors, Leptin - metabolism
Treatment Outcome
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Title Leptin, Leptin Soluble Receptor, and the Free Leptin Index following a Diet and Physical Activity Lifestyle Intervention in Obese Males and Females
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