Reverse Nearest Neighbor Search on a Protein-Protein Interaction Network to Infer Protein-Disease Associations

• Published in: Bioinformatics and Biology Insights Vol. 2017; no. 11; pp. 1 - 11-010
• Main Authors: Suratanee, Apichat, Plaimas, Kitiporn
• Format: Journal Article
• Language: English
• Published: London, England Libertas Academica 2017; SAGE Publishing; SAGE Publications; Sage Publications Ltd
• Subjects: Authorship; Cluster analysis; Datasets; Disease; Diseases; Genes; Literature searches; Medical Subject Headings-MeSH; Methods; Original Research; Peer review; Protein interaction; Proteins; Searching; Studies; network-based method; protein-disease associations; reverse nearest neighbor search

The associations between proteins and diseases are crucial information for investigating pathological mechanisms. However, the number of known and reliable protein-disease associations is quite small. In this study, an analysis framework to infer associations between proteins and diseases was develo...