Comparative Effectiveness of Darunavir 1,200 mg Daily and Approved Dosing Strategies for Protease Inhibitor-Experienced Patients

• Published in: AIDS Research and Treatment Vol. 2013; no. 2013; pp. 1 - 4
• Main Authors: Mikula, James M., Hsiao, Chiu-Bin, Sawyer, Joshua R., Ma, Qing, Morse, Gene D.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2013; Hindawi Puplishing Corporation; Hindawi Publishing Corporation; Hindawi Limited; Wiley
• Subjects: Antiretroviral drugs; Comparative analysis; Complications and side effects; Darunavir; Dosage and administration; Drug dosages; Drug resistance; Drug therapy; HIV; HIV infection; Human immunodeficiency virus; Patients; Protease inhibitors; United States

Background. HIV protease inhibitors exhibit concentration-dependent viral inhibition. Higher once daily doses of darunavir boosted with ritonavir (DRV/r) may achieve viral suppression in place of twice daily dosing. International antiretroviral adherence guidelines recommend once daily regimens when...