Toward Reliable Lipoprotein Particle Predictions from NMR Spectra of Human Blood: An Interlaboratory Ring Test

• Published in: Analytical chemistry (Washington) Vol. 89; no. 15; pp. 8004 - 8012
• Main Authors: Monsonis Centelles, Sandra, Hoefsloot, Huub C. J, Khakimov, Bekzod, Ebrahimi, Parvaneh, Lind, Mads V, Kristensen, Mette, de Roo, Niels, Jacobs, Doris M, van Duynhoven, John, Cannet, Claire, Fang, Fang, Humpfer, Eberhard, Schäfer, Hartmut, Spraul, Manfred, Engelsen, Søren B, Smilde, Age K
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.08.2017
• Subjects: Adult; Analytical chemistry; Biofysica; Biomarkers; Biophysics; Blood; blood serum; Chemistry; Cholesterol; Diagnostic systems; Europe; Female; High density lipoprotein; High performance liquid chromatography; Humans; Laboratories; Laboratories - standards; Laboratorium voor Biofysica; Least-Squares Analysis; Lipoproteins; Lipoproteins, HDL - blood; Lipoproteins, LDL - blood; Lipoproteins, VLDL - blood; Liquid chromatography; Low density lipoprotein; Measurement; NMR; Nuclear magnetic resonance; nuclear magnetic resonance spectroscopy; Nutrition; prediction; Prediction models; Pregnancy; Principal Component Analysis; Proton Magnetic Resonance Spectroscopy - standards; Quality control; Reliability; Reproducibility; Spectra; Spectroscopy; Standardization; Ultracentrifugation; variance; Variance analysis; VLAG; Young Adult; Europe

Lipoprotein profiling of human blood by 1H nuclear magnetic resonance (NMR) spectroscopy is a rapid and promising approach to monitor health and disease states in medicine and nutrition. However, lack of standardization of measurement protocols has prevented the use of NMR-based lipoprotein profilin...