Structure and regulation of the type VI secretion system

• Published in: Annual review of microbiology Vol. 66; p. 453
• Main Authors: Silverman, Julie M, Brunet, Yannick R, Cascales, Eric, Mougous, Joseph D
• Format: Journal Article
• Language: English
• Published: United States 01.01.2012
• Subjects: Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacterial Secretion Systems - genetics; Gram-Negative Bacteria - genetics; Gram-Negative Bacteria - metabolism; Membrane Transport Proteins - genetics; Membrane Transport Proteins - metabolism; Multiprotein Complexes - genetics; Multiprotein Complexes - metabolism; Protein Binding; Protein Multimerization

The type VI secretion system (T6SS) is a complex and widespread gram-negative bacterial export pathway with the capacity to translocate protein effectors into a diversity of target cell types. Current structural models of the T6SS indicate that the apparatus is composed of at least two complexes, a...