Structure and regulation of the type VI secretion system
The type VI secretion system (T6SS) is a complex and widespread gram-negative bacterial export pathway with the capacity to translocate protein effectors into a diversity of target cell types. Current structural models of the T6SS indicate that the apparatus is composed of at least two complexes, a...
Saved in:
| Published in | Annual review of microbiology Vol. 66; p. 453 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.01.2012
|
| Subjects | |
| Online Access | Get more information |
Cover
Loading…
| Abstract | The type VI secretion system (T6SS) is a complex and widespread gram-negative bacterial export pathway with the capacity to translocate protein effectors into a diversity of target cell types. Current structural models of the T6SS indicate that the apparatus is composed of at least two complexes, a dynamic bacteriophage-like structure and a cell-envelope-spanning membrane-associated assembly. How these complexes interact to promote effector secretion and cell targeting remains a major question in the field. As a contact-dependent pathway with specific cellular targets, the T6SS is subject to tight regulation. Thus, the identification of regulatory elements that control T6S expression continues to shape our understanding of the environmental circumstances relevant to its function. This review discusses recent progress toward characterizing T6S structure and regulation. |
|---|---|
| AbstractList | The type VI secretion system (T6SS) is a complex and widespread gram-negative bacterial export pathway with the capacity to translocate protein effectors into a diversity of target cell types. Current structural models of the T6SS indicate that the apparatus is composed of at least two complexes, a dynamic bacteriophage-like structure and a cell-envelope-spanning membrane-associated assembly. How these complexes interact to promote effector secretion and cell targeting remains a major question in the field. As a contact-dependent pathway with specific cellular targets, the T6SS is subject to tight regulation. Thus, the identification of regulatory elements that control T6S expression continues to shape our understanding of the environmental circumstances relevant to its function. This review discusses recent progress toward characterizing T6S structure and regulation. |
| Author | Mougous, Joseph D Silverman, Julie M Brunet, Yannick R Cascales, Eric |
| Author_xml | – sequence: 1 givenname: Julie M surname: Silverman fullname: Silverman, Julie M organization: Department of Microbiology, University of Washington, Seattle, 98195, USA – sequence: 2 givenname: Yannick R surname: Brunet fullname: Brunet, Yannick R – sequence: 3 givenname: Eric surname: Cascales fullname: Cascales, Eric – sequence: 4 givenname: Joseph D surname: Mougous fullname: Mougous, Joseph D |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22746332$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1j0lLBDEYRIMozqJ_QQKeo_mydo4y6Dgw4MHlOmSyaMt0uknSwvx7G5dTHap4vFqg09SngNA10BsAoW5tSmMOX6RrXe4JMGioISBBgTlBc5BCEs4kzNCilE9KqdDUnKMZY1ooztkcNc81j65OEGyTxzm8jwdb2z7hPuL6EXA9DgG_bXAJLoefohxLDd0FOov2UMLlXy7R68P9y-qRbJ_Wm9XdllglTCXSxH3U1mkuGstM0Io5DsJOIr6JMElE5q0RSjLgVkXlrW648JFK46YRW6KrX-4w7rvgd0NuO5uPu_8L7Bsw5Ewi |
| CitedBy_id | crossref_primary_10_1111_1462_2920_14085 crossref_primary_10_1016_j_tim_2018_01_006 crossref_primary_10_1073_pnas_1300627110 crossref_primary_10_1111_mmi_13292 crossref_primary_10_1098_rstb_2015_0021 crossref_primary_10_1128_JB_00528_16 crossref_primary_10_1080_21505594_2016_1258507 crossref_primary_10_1016_j_jmb_2018_07_018 crossref_primary_10_3389_fmicb_2022_869278 crossref_primary_10_1016_j_ijbiomac_2018_09_166 crossref_primary_10_1371_journal_pone_0123061 crossref_primary_10_1007_s12275_015_5055_y crossref_primary_10_1038_s41396_019_0353_8 crossref_primary_10_1186_1471_2164_15_243 crossref_primary_10_1007_s10123_023_00461_y crossref_primary_10_21307_PM_2018_57_4_360 crossref_primary_10_1371_journal_pone_0086918 crossref_primary_10_1002_embr_201337936 crossref_primary_10_1042_BJ20130193 crossref_primary_10_1073_pnas_1222783110 crossref_primary_10_1146_annurev_phyto_011014_015624 crossref_primary_10_1186_s12864_015_2000_8 crossref_primary_10_3389_fmicb_2017_02473 crossref_primary_10_1016_j_celrep_2019_08_096 crossref_primary_10_1038_ncomms7453 crossref_primary_10_3390_molecules23051009 crossref_primary_10_1371_journal_ppat_1007969 crossref_primary_10_1128_MMBR_00037_15 crossref_primary_10_1371_journal_pone_0240908 crossref_primary_10_15252_embr_202051857 crossref_primary_10_1007_s13205_020_02311_4 crossref_primary_10_1128_IAI_00562_19 crossref_primary_10_1186_1471_2180_13_92 crossref_primary_10_3390_microorganisms8050622 crossref_primary_10_1371_journal_pone_0076767 crossref_primary_10_1128_JB_00906_15 crossref_primary_10_3390_toxins17030099 crossref_primary_10_1007_s13213_015_1156_4 crossref_primary_10_1038_srep23080 crossref_primary_10_1007_s12275_015_4539_0 crossref_primary_10_1016_j_micpath_2020_104579 crossref_primary_10_1007_s13205_020_02296_0 crossref_primary_10_1016_j_chom_2013_05_002 crossref_primary_10_1016_j_resmic_2013_03_017 crossref_primary_10_1016_j_mib_2012_11_009 crossref_primary_10_1159_000351360 crossref_primary_10_1099_ijsem_0_005586 crossref_primary_10_1038_s41467_023_44426_1 crossref_primary_10_3389_fcimb_2018_00260 crossref_primary_10_3390_microorganisms8081253 crossref_primary_10_1186_s12864_016_2377_z crossref_primary_10_3389_fimmu_2025_1563450 crossref_primary_10_1038_s41564_018_0238_z crossref_primary_10_1128_mBio_00712_15 crossref_primary_10_3389_fmicb_2017_02212 crossref_primary_10_1107_S0907444913022725 crossref_primary_10_3390_ijms22168632 crossref_primary_10_1128_mBio_01253_16 crossref_primary_10_3390_antibiotics12020195 crossref_primary_10_1016_j_micres_2023_127501 crossref_primary_10_1038_srep36891 crossref_primary_10_1074_mcp_M113_030502 crossref_primary_10_3389_fmicb_2014_00588 crossref_primary_10_1016_j_tim_2013_02_003 crossref_primary_10_1128_ecosalplus_esp_0009_2015 crossref_primary_10_1007_s12275_021_1189_2 crossref_primary_10_1371_journal_pone_0063917 crossref_primary_10_1128_IAI_01544_14 crossref_primary_10_1074_mcp_M116_061044 crossref_primary_10_1007_s00203_024_04060_x crossref_primary_10_1016_j_jip_2014_10_009 crossref_primary_10_1107_S1399004714001242 crossref_primary_10_7717_peerj_791 crossref_primary_10_1186_s12934_024_02540_9 crossref_primary_10_1128_genomeA_00919_13 crossref_primary_10_1016_j_bbrc_2023_09_091 crossref_primary_10_1016_j_bbrc_2019_06_020 crossref_primary_10_3389_fcimb_2024_1297818 crossref_primary_10_1016_j_molimm_2019_04_016 crossref_primary_10_1152_ajpcell_00277_2013 crossref_primary_10_3389_fmicb_2020_612568 crossref_primary_10_1094_MPMI_07_14_0219_R crossref_primary_10_1186_1471_2164_14_761 crossref_primary_10_1016_j_jmb_2018_02_008 crossref_primary_10_1038_s41467_019_10466_9 crossref_primary_10_1038_srep08235 crossref_primary_10_3389_fagro_2021_661468 crossref_primary_10_1016_j_jcf_2014_03_004 crossref_primary_10_1128_microbiolspec_UTI_0017_2013 crossref_primary_10_1016_j_chom_2013_11_008 crossref_primary_10_1128_JB_01962_12 crossref_primary_10_1007_s40475_017_0119_1 crossref_primary_10_1073_pnas_1608858113 crossref_primary_10_1016_j_jbc_2025_108242 crossref_primary_10_1128_mBio_00410_12 crossref_primary_10_1111_1574_6976_12079 crossref_primary_10_1128_MMBR_00064_12 crossref_primary_10_1074_jbc_M113_499772 crossref_primary_10_1111_tra_12488 crossref_primary_10_1016_j_micpath_2015_01_006 crossref_primary_10_1073_pnas_1512124112 crossref_primary_10_1016_j_molcel_2013_07_025 crossref_primary_10_3390_pathogens12010008 crossref_primary_10_1016_j_foodres_2021_110541 crossref_primary_10_1186_1471_2105_15_244 crossref_primary_10_3934_biophy_2015_2_88 crossref_primary_10_1186_s13567_019_0658_7 crossref_primary_10_1128_JB_00863_13 crossref_primary_10_1371_journal_pone_0265884 crossref_primary_10_1016_j_micres_2018_02_004 crossref_primary_10_3389_fmicb_2022_1042111 crossref_primary_10_1073_pnas_1525637113 crossref_primary_10_1128_JB_00075_20 crossref_primary_10_1093_infdis_jiy534 crossref_primary_10_1186_s13099_020_00357_6 crossref_primary_10_1128_microbiolspec_VMBF_0026_2015 crossref_primary_10_1371_journal_pone_0067647 crossref_primary_10_3389_fmicb_2019_01484 crossref_primary_10_7554_eLife_00868 crossref_primary_10_7717_peerj_529 crossref_primary_10_1016_j_cell_2015_09_027 crossref_primary_10_3389_fmicb_2018_00962 crossref_primary_10_1093_pnasnexus_pgad195 crossref_primary_10_1016_j_jmb_2017_11_015 crossref_primary_10_1111_zph_12176 crossref_primary_10_3389_fmicb_2018_01819 crossref_primary_10_3389_fcimb_2022_964710 crossref_primary_10_1038_nature12074 crossref_primary_10_1038_s41598_018_37422_9 crossref_primary_10_1371_journal_pone_0089411 crossref_primary_10_1016_j_micres_2015_01_004 crossref_primary_10_1042_BCJ20180077 crossref_primary_10_1371_journal_pgen_1005545 crossref_primary_10_1080_21505594_2016_1168550 crossref_primary_10_1016_j_abb_2024_109939 crossref_primary_10_1038_s41467_025_56309_8 crossref_primary_10_1186_s12864_019_5885_9 crossref_primary_10_2174_0109298673252910230920151332 crossref_primary_10_1128_spectrum_02852_23 crossref_primary_10_2174_1389450123666220309101345 crossref_primary_10_1111_2049_632X_12167 crossref_primary_10_1016_j_tim_2017_01_005 crossref_primary_10_3390_biom11060892 crossref_primary_10_1128_IAI_00198_15 crossref_primary_10_1159_000351625 crossref_primary_10_1016_j_resmic_2013_05_004 crossref_primary_10_1371_journal_ppat_1010182 crossref_primary_10_1038_s41385_018_0053_0 crossref_primary_10_1099_mic_0_078279_0 crossref_primary_10_1186_s13567_019_0683_6 crossref_primary_10_1007_s10529_013_1396_y crossref_primary_10_1016_j_bbamcr_2013_12_020 crossref_primary_10_1038_s41598_021_85218_1 crossref_primary_10_1016_j_celrep_2012_11_027 crossref_primary_10_1016_j_csbj_2020_11_025 crossref_primary_10_1016_j_micpath_2021_105085 crossref_primary_10_1371_journal_pone_0110810 crossref_primary_10_1111_hel_12038 crossref_primary_10_1128_mBio_03060_19 crossref_primary_10_1007_s00284_014_0526_7 crossref_primary_10_1371_journal_pone_0081074 crossref_primary_10_1111_1462_2920_15905 crossref_primary_10_1186_1471_2164_15_535 crossref_primary_10_1111_1462_2920_12516 crossref_primary_10_1093_bib_bbx078 crossref_primary_10_1128_AEM_01611_19 crossref_primary_10_3389_fmicb_2020_00202 crossref_primary_10_1128_MMBR_00052_14 crossref_primary_10_3389_fmicb_2022_840308 crossref_primary_10_1016_j_mib_2013_11_002 crossref_primary_10_1099_mic_0_001367 crossref_primary_10_1093_gbe_evu262 crossref_primary_10_1099_mgen_0_000750 crossref_primary_10_3389_fcimb_2017_00132 crossref_primary_10_3389_fmicb_2019_02379 crossref_primary_10_1016_j_micres_2021_126722 crossref_primary_10_1007_s12275_022_2109_9 crossref_primary_10_1042_BCJ20230240 crossref_primary_10_1371_journal_ppat_1003991 crossref_primary_10_1002_jobm_201800156 crossref_primary_10_1016_j_csbj_2020_11_003 crossref_primary_10_1186_s12864_019_5831_x crossref_primary_10_1093_femsec_fiz054 crossref_primary_10_1371_journal_ppat_1008198 crossref_primary_10_1128_spectrum_00941_23 crossref_primary_10_15252_embr_201643206 crossref_primary_10_1007_s10327_013_0443_9 crossref_primary_10_1371_journal_pone_0076030 crossref_primary_10_18036_estubtdc_599174 crossref_primary_10_1371_journal_pgen_1004255 crossref_primary_10_7554_eLife_05701 crossref_primary_10_1007_s00253_016_7486_8 crossref_primary_10_1111_mmi_14513 crossref_primary_10_3389_fcimb_2017_00265 crossref_primary_10_1111_mmi_12571 crossref_primary_10_1042_BJ20131426 crossref_primary_10_1016_j_chom_2016_10_008 crossref_primary_10_3390_biom15010091 crossref_primary_10_1128_mbio_03025_24 crossref_primary_10_1371_journal_pone_0059388 crossref_primary_10_1139_cjm_2013_0343 crossref_primary_10_1128_mBio_02761_19 crossref_primary_10_3390_pathogens9070559 crossref_primary_10_1111_1462_2920_15255 crossref_primary_10_1128_mBio_00895_17 crossref_primary_10_1111_1462_2920_14282 crossref_primary_10_1016_j_micpath_2014_06_006 crossref_primary_10_3389_fmicb_2020_01799 crossref_primary_10_1002_mbo3_90 crossref_primary_10_1016_j_rhisph_2022_100582 crossref_primary_10_1016_j_str_2014_02_012 crossref_primary_10_1107_S2053230X14017397 crossref_primary_10_3390_biology12050678 crossref_primary_10_1093_ismejo_wrae151 crossref_primary_10_1371_journal_ppat_1006325 crossref_primary_10_1002_bies_201600262 crossref_primary_10_1128_spectrum_01170_23 crossref_primary_10_1186_s12864_017_3842_z crossref_primary_10_1073_pnas_1502966112 crossref_primary_10_1016_j_foodres_2023_113143 crossref_primary_10_1128_mSystems_00312_18 crossref_primary_10_1038_s41579_023_00877_3 crossref_primary_10_1111_1462_2920_12794 crossref_primary_10_1128_JB_00214_13 crossref_primary_10_1016_j_aquaculture_2021_737701 crossref_primary_10_1099_mic_0_001376 crossref_primary_10_1016_j_resmic_2019_10_004 crossref_primary_10_1128_mSphere_00462_17 crossref_primary_10_1128_spectrum_05045_22 crossref_primary_10_3389_fcimb_2015_00070 crossref_primary_10_3389_fmicb_2019_00459 crossref_primary_10_1128_microbiolspec_PSIB_0031_2019 crossref_primary_10_1016_j_aquaculture_2023_740102 crossref_primary_10_1371_journal_ppat_1004933 crossref_primary_10_1038_nmeth_2961 crossref_primary_10_1016_j_cell_2015_02_005 crossref_primary_10_1094_MPMI_01_18_0026_R crossref_primary_10_1111_omi_12238 crossref_primary_10_1016_j_bbamcr_2014_03_018 crossref_primary_10_1007_s00248_021_01892_8 crossref_primary_10_1007_s11515_014_1333_z crossref_primary_10_3390_genes14111979 crossref_primary_10_1016_j_ijmm_2018_06_007 crossref_primary_10_3389_fmicb_2017_01454 crossref_primary_10_1128_JB_00777_19 crossref_primary_10_1371_journal_pone_0158866 crossref_primary_10_3389_fmicb_2019_01635 crossref_primary_10_1111_1574_6968_12180 crossref_primary_10_1094_MPMI_01_19_0021_R crossref_primary_10_1093_infdis_jit482 crossref_primary_10_1128_microbiolspec_RWR_0002_2017 crossref_primary_10_1007_s44154_022_00081_y crossref_primary_10_1111_evo_13491 crossref_primary_10_3390_ijms21218128 crossref_primary_10_1038_nrmicro3185 crossref_primary_10_1128_mBio_01645_17 crossref_primary_10_1038_s41467_024_54509_2 crossref_primary_10_1107_S1399004714023967 crossref_primary_10_1007_s12033_024_01248_w crossref_primary_10_1038_nature14667 crossref_primary_10_1038_s41598_020_77612_y crossref_primary_10_1128_mSystems_00171_16 crossref_primary_10_1074_mcp_RA119_001532 crossref_primary_10_1371_journal_ppat_1003393 crossref_primary_10_1371_journal_pone_0244217 crossref_primary_10_1099_mic_0_063495_0 crossref_primary_10_1093_nar_gkad667 crossref_primary_10_1074_jbc_M112_439273 crossref_primary_10_1371_journal_pone_0283583 crossref_primary_10_1016_j_tim_2012_08_003 crossref_primary_10_1016_j_cell_2016_08_023 crossref_primary_10_1080_21505594_2017_1323164 crossref_primary_10_1128_JB_01865_14 crossref_primary_10_1134_S0003683820020106 crossref_primary_10_1371_journal_pone_0055142 crossref_primary_10_3390_plants11010034 crossref_primary_10_1371_journal_ppat_1004592 crossref_primary_10_1111_1462_2920_14039 crossref_primary_10_1007_s00203_022_02807_y crossref_primary_10_1073_pnas_1213963109 crossref_primary_10_2147_IDR_S426657 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.1146/annurev-micro-121809-151619 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1545-3251 |
| ExternalDocumentID | 22746332 |
| Genre | Research Support, U.S. Gov't, P.H.S Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: T32 GM07270 – fundername: NIAID NIH HHS grantid: AI080609 – fundername: NIAID NIH HHS grantid: R01 AI080609 – fundername: NIAID NIH HHS grantid: U54 AI057141 – fundername: NIGMS NIH HHS grantid: T32 GM007270 – fundername: NIAID NIH HHS grantid: AI057141 |
| GroupedDBID | --- -QD -QH -~X .GJ 0R~ 1KX 23M 36B 39C 3O- 4.4 4P2 51A 53G 5FA 5FB 5FC 5FD 5FE 5FF 5FH 5GY 6J9 70K 70N 70Q 70S 70W 79. 7A. 7B- 7X7 85S 88E 88I 8AF 8AO 8CJ 8FE 8FH 8FI 8FJ 8G5 8NG 8R4 8R5 AABJL AAGWO AALHT AALUV AAOHI AAQMF AARJV AAWJP AAXSQ AAYIS ABDBF ABDOG ABDPE ABGRM ABIPL ABJNI ABKGM ABPPZ ABUWG ABVYV ABZNY ACAHA ACDVT ACGFO ACGFS ACGOD ACJYF ACKHT ACKOT ACMXS ACNCT ACPHO ACPRK ACQCJ ACRLM ACSOE ACUHS ADANS ADBBV ADEJD ADHEY ADIYS ADLON ADNJN ADSVE AEAIQ AEKBM AENEX AEPIK AEUYN AFCZG AFERR AFFDN AFKDQ AFKEJ AFKRA AFONB AFRAH AGBCJ AGNAY AHDLI AHIXL AHKZM AHMBA AHVNO AI. AICBU AIDEK AIJFW AIZOL AJAAW ALAFQ ALIPV ALMA_UNASSIGNED_HOLDINGS AMTJG AOUBY AQQLW ATAUN AZQEC B0M B9D B9E B9F B9G B9H B9L B9N BBNVY BCFVH BENPR BES BHPHI BJPMW BKOMP BKSAR BMYRD BPHCQ BVXVI CCPQU CGR CJ0 CS3 CUY CVF D1J DWQXO EAP EAS EBC EBD EBS ECM EDH EIF EJD EMB EMK EMOBN EST ESX F-Q F-S F-V F-X F-Y F-Z F5P FIWKU FIXEU FMZAJ FQMFW FT0 FU. FUEKT FXG FYUFA GJQJI GLOEX GNDDA GNUQQ GOAVI GQXMV GUQSH H13 HCIFZ HMCUK HZ~ H~9 IAG IAO IEA IEP IGS IH2 IHR IOF ITC J1V L7B LK8 M1P M22 M2O M2P M7P MM. MVM N9A NPM O9- OHT P0P P2P PADUT PCBAR PHGZT PQQKQ PROAC PSQYO Q2X R05 RAR RAV RNS RXW SV3 TAE TAF TUS UKHRP UKR UMF VH1 WH7 X6Y X7N XOL XSW YSK YYQ YZZ ZE2 ZGI ZYWBE ~02 ~8M ~KM |
| ID | FETCH-LOGICAL-a649t-59fbf7ac7348a29e762c314a470d8f1633f2da9465213a6f6da7834df059c4702 |
| IngestDate | Thu Apr 03 07:07:02 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-a649t-59fbf7ac7348a29e762c314a470d8f1633f2da9465213a6f6da7834df059c4702 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/3595004 |
| PMID | 22746332 |
| ParticipantIDs | pubmed_primary_22746332 |
| PublicationCentury | 2000 |
| PublicationDate | 2012-01-01 |
| PublicationDateYYYYMMDD | 2012-01-01 |
| PublicationDate_xml | – month: 01 year: 2012 text: 2012-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Annual review of microbiology |
| PublicationTitleAlternate | Annu Rev Microbiol |
| PublicationYear | 2012 |
| References | 18289922 - Curr Opin Microbiol. 2008 Feb;11(1):3-8 9457432 - Clin Microbiol Rev. 1998 Jan;11(1):142-201 15659669 - J Bacteriol. 2005 Feb;187(3):912-22 21325275 - J Biol Chem. 2011 Apr 8;286(14):12317-27 19624706 - Environ Microbiol. 2009 Dec;11(12):3018-28 22367545 - Nature. 2012 Mar 8;483(7388):182-6 19258189 - Best Pract Res Clin Gastroenterol. 2009;23(1):89-99 18805985 - J Bacteriol. 2008 Nov;190(22):7523-31 20638635 - Cell Host Microbe. 2010 Jul 22;8(1):2-6 11282468 - Curr Opin Microbiol. 2001 Apr;4(2):138-44 18566662 - PLoS Pathog. 2008 Jun;4(6):e1000093 15546607 - Mol Cell. 2004 Nov 19;16(4):497-8 8763923 - J Bacteriol. 1996 Jul;178(14):3996-4003 16458574 - Curr Opin Microbiol. 2006 Apr;9(2):201-6 20621482 - Trends Biochem Sci. 2010 Dec;35(12):691-8 20472799 - J Bacteriol. 2010 Jul;192(14):3584-96 22017253 - Mol Microbiol. 2011 Dec;82(5):1277-90 19276114 - Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4067-8 22371492 - J Biol Chem. 2012 Apr 20;287(17):14157-68 12542086 - Dis Aquat Organ. 2002 Nov 22;52(2):93-107 15639629 - Trends Microbiol. 2005 Jan;13(1):27-33 19602144 - Mol Microbiol. 2009 Aug;73(3):434-45 21949076 - J Bacteriol. 2011 Dec;193(23):6471-82 21705592 - J Bacteriol. 2011 Aug;193(16):4224-37 22120744 - Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1065-72 19880608 - J Bacteriol. 2010 Jan;192(1):155-68 17041629 - Nat Rev Microbiol. 2006 Nov;4(11):811-25 15525535 - Dev Cell. 2004 Nov;7(5):745-54 18310321 - Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3733-8 20886112 - PLoS One. 2010;5(9):e12910 19563898 - Fish Shellfish Immunol. 2009 Sep;27(3):469-77 8830233 - Mol Microbiol. 1996 Feb;19(3):409-16 17304251 - Nat Rev Microbiol. 2007 Mar;5(3):230-9 19946141 - Microbiol Mol Biol Rev. 2009 Dec;73(4):775-808 20487285 - Mol Microbiol. 2010 Feb;75(4):886-99 22083711 - Infect Immun. 2012 Feb;80(2):575-84 19497948 - Microbiology. 2009 Sep;155(Pt 9):2845-55 8122363 - Virology. 1994 Mar;199(2):301-10 16451173 - FEMS Microbiol Lett. 2006 Jan;254(1):12-8 18047567 - Mol Microbiol. 2008 Jan;67(2):241-53 20089046 - Environ Microbiol. 2010 Apr;12(4):899-915 21084635 - Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21128-33 21047256 - Annu Rev Genet. 2010;44:71-90 22393043 - J Biol Chem. 2012 May 4;287(19):15610-21 21776080 - Nature. 2011 Jul 21;475(7356):343-7 21776071 - Nature. 2011 Jul 21;475(7356):301-3 16531068 - J Struct Biol. 2006 Oct;156(1):190-9 21555399 - Infect Immun. 2011 Jul;79(7):2941-9 2848245 - Proc Natl Acad Sci U S A. 1988 Dec;85(23):8919-23 21909372 - PLoS One. 2011;6(8):e23876 21778203 - Microbiology. 2011 Oct;157(Pt 10):2954-62 21784934 - J Bacteriol. 2011 Oct;193(19):5510-3 20114026 - Cell Host Microbe. 2010 Jan 21;7(1):25-37 20974937 - Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19520-4 20511495 - J Bacteriol. 2010 Aug;192(15):3850-60 10712695 - Mol Microbiol. 2000 Mar;35(5):1146-55 19400797 - Mol Microbiol. 2009 Jun;72(5):1111-25 19243444 - FEMS Microbiol Rev. 2009 Mar;33(2):279-94 19286133 - Cell Host Microbe. 2009 Mar 19;5(3):234-43 19284603 - BMC Genomics. 2009;10:104 19131969 - EMBO J. 2009 Feb 18;28(4):315-25 16954050 - Microb Pathog. 2006 Dec;41(6):207-17 19729404 - Microbiology. 2009 Nov;155(Pt 11):3518-31 22411981 - Philos Trans R Soc Lond B Biol Sci. 2012 Apr 19;367(1592):1102-11 21378190 - J Bacteriol. 2011 May;193(9):2158-67 19251647 - Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4160-5 16432199 - Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1528-33 17873062 - Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15508-13 19701456 - PLoS One. 2009;4(8):e6734 17098922 - Appl Environ Microbiol. 2007 Jan;73(2):650-4 21743810 - Front Microbiol. 2011 Jun 27;2:136 21298257 - Arch Microbiol. 2011 May;193(5):351-63 20593364 - Macromol Biosci. 2010 Jul 7;10(7):808-13 11823865 - Nature. 2002 Jan 31;415(6871):553-7 14597753 - J Clin Invest. 2003 Nov;112(9):1291-9 16925558 - Mol Microbiol. 2006 Sep;61(5):1267-82 19395482 - J Bacteriol. 2009 Jul;191(13):4316-29 20729192 - J Biol Chem. 2010 Nov 12;285(46):35988-98 15093831 - Curr Opin Struct Biol. 2004 Apr;14(2):171-80 4933424 - J Mol Biol. 1971 Jun 28;58(3):693-709 19426209 - Mol Microbiol. 2009 May;72(3):612-32 20865170 - PLoS Pathog. 2010;6(8):e1001068 12127983 - Biochem Biophys Res Commun. 2002 Jul 26;295(4):922-8 8824613 - J Bacteriol. 1996 Oct;178(19):5683-91 20971679 - Curr Opin Microbiol. 2011 Feb;14(1):9-15 3308853 - J Bacteriol. 1987 Oct;169(10):4759-64 8491699 - J Bacteriol. 1993 May;175(10):2793-8 20961764 - Trends Microbiol. 2010 Dec;18(12):531-7 11700290 - Annu Rev Genet. 2001;35:439-68 20444095 - Mol Microbiol. 2010 May;76(4):815-21 15049819 - Mol Microbiol. 2004 Apr;52(1):169-87 19686078 - Annu Rev Genet. 2009;43:197-222 11807075 - J Bacteriol. 2002 Feb;184(4):1140-54 19251641 - Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4154-9 21953460 - J Biol Chem. 2011 Nov 11;286(45):39417-30 16760520 - Am J Trop Med Hyg. 2006 Jun;74(6):1060-6 19201795 - J Bacteriol. 2009 Apr;191(8):2431-46 6096021 - Cell. 1984 Dec;39(3 Pt 2):691-8 11932449 - Microbiology. 2002 Apr;148(Pt 4):1039-48 17986187 - Mol Microbiol. 2007 Dec;66(5):1192-206 22102820 - PLoS Pathog. 2011 Nov;7(11):e1002386 16373506 - Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):171-6 21178498 - Virulence. 2010 Nov-Dec;1(6):535-40 21873404 - Microbiology. 2011 Dec;157(Pt 12):3292-305 21476004 - J Struct Funct Genomics. 2011 Mar;12(1):21-6 17993530 - J Bacteriol. 2008 Jan;190(2):476-86 21112241 - Curr Opin Microbiol. 2011 Feb;14(1):3-8 1356964 - J Bacteriol. 1992 Oct;174(19):6061-70 21551284 - Appl Environ Microbiol. 2011 Jul;77(13):4293-302 15686562 - Mol Microbiol. 2005 Feb;55(4):1160-82 18617888 - EMBO Rep. 2008 Aug;9(8):735-41 19364842 - Infect Immun. 2009 Jul;77(7):2590-601 21361789 - Mol Plant Microbe Interact. 2011 Jul;24(7):751-7 22950014 - Microbiologyopen. 2012 Mar;1(1):71-82 10334980 - Science. 1999 May 21;284(5418):1318-22 4933423 - J Mol Biol. 1971 Jun 28;58(3):685-92 21829382 - PLoS Genet. 2011 Jul;7(7):e1002205 19756009 - Nat Rev Microbiol. 2009 Oct;7(10):703-14 19229296 - EMBO J. 2009 Apr 8;28(7):821-9 17157497 - Curr Opin Struct Biol. 2007 Feb;17(1):110-6 16763151 - Science. 2006 Jun 9;312(5779):1526-30 17558395 - Nat Cell Biol. 2007 Jul;9(7):797-803 |
| References_xml | – reference: 17986187 - Mol Microbiol. 2007 Dec;66(5):1192-206 – reference: 19880608 - J Bacteriol. 2010 Jan;192(1):155-68 – reference: 21325275 - J Biol Chem. 2011 Apr 8;286(14):12317-27 – reference: 11282468 - Curr Opin Microbiol. 2001 Apr;4(2):138-44 – reference: 15049819 - Mol Microbiol. 2004 Apr;52(1):169-87 – reference: 19364842 - Infect Immun. 2009 Jul;77(7):2590-601 – reference: 16954050 - Microb Pathog. 2006 Dec;41(6):207-17 – reference: 21112241 - Curr Opin Microbiol. 2011 Feb;14(1):3-8 – reference: 21776080 - Nature. 2011 Jul 21;475(7356):343-7 – reference: 21778203 - Microbiology. 2011 Oct;157(Pt 10):2954-62 – reference: 21705592 - J Bacteriol. 2011 Aug;193(16):4224-37 – reference: 18310321 - Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3733-8 – reference: 6096021 - Cell. 1984 Dec;39(3 Pt 2):691-8 – reference: 16432199 - Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1528-33 – reference: 17157497 - Curr Opin Struct Biol. 2007 Feb;17(1):110-6 – reference: 15546607 - Mol Cell. 2004 Nov 19;16(4):497-8 – reference: 10712695 - Mol Microbiol. 2000 Mar;35(5):1146-55 – reference: 19563898 - Fish Shellfish Immunol. 2009 Sep;27(3):469-77 – reference: 20089046 - Environ Microbiol. 2010 Apr;12(4):899-915 – reference: 22371492 - J Biol Chem. 2012 Apr 20;287(17):14157-68 – reference: 11700290 - Annu Rev Genet. 2001;35:439-68 – reference: 8122363 - Virology. 1994 Mar;199(2):301-10 – reference: 16451173 - FEMS Microbiol Lett. 2006 Jan;254(1):12-8 – reference: 20444095 - Mol Microbiol. 2010 May;76(4):815-21 – reference: 22083711 - Infect Immun. 2012 Feb;80(2):575-84 – reference: 15686562 - Mol Microbiol. 2005 Feb;55(4):1160-82 – reference: 21909372 - PLoS One. 2011;6(8):e23876 – reference: 19729404 - Microbiology. 2009 Nov;155(Pt 11):3518-31 – reference: 16763151 - Science. 2006 Jun 9;312(5779):1526-30 – reference: 22393043 - J Biol Chem. 2012 May 4;287(19):15610-21 – reference: 19701456 - PLoS One. 2009;4(8):e6734 – reference: 20593364 - Macromol Biosci. 2010 Jul 7;10(7):808-13 – reference: 10334980 - Science. 1999 May 21;284(5418):1318-22 – reference: 21476004 - J Struct Funct Genomics. 2011 Mar;12(1):21-6 – reference: 15639629 - Trends Microbiol. 2005 Jan;13(1):27-33 – reference: 20865170 - PLoS Pathog. 2010;6(8):e1001068 – reference: 8763923 - J Bacteriol. 1996 Jul;178(14):3996-4003 – reference: 21551284 - Appl Environ Microbiol. 2011 Jul;77(13):4293-302 – reference: 11823865 - Nature. 2002 Jan 31;415(6871):553-7 – reference: 20472799 - J Bacteriol. 2010 Jul;192(14):3584-96 – reference: 17041629 - Nat Rev Microbiol. 2006 Nov;4(11):811-25 – reference: 15093831 - Curr Opin Struct Biol. 2004 Apr;14(2):171-80 – reference: 21555399 - Infect Immun. 2011 Jul;79(7):2941-9 – reference: 22102820 - PLoS Pathog. 2011 Nov;7(11):e1002386 – reference: 16373506 - Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):171-6 – reference: 20974937 - Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19520-4 – reference: 20621482 - Trends Biochem Sci. 2010 Dec;35(12):691-8 – reference: 15525535 - Dev Cell. 2004 Nov;7(5):745-54 – reference: 20886112 - PLoS One. 2010;5(9):e12910 – reference: 8824613 - J Bacteriol. 1996 Oct;178(19):5683-91 – reference: 3308853 - J Bacteriol. 1987 Oct;169(10):4759-64 – reference: 19251641 - Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4154-9 – reference: 21743810 - Front Microbiol. 2011 Jun 27;2:136 – reference: 21378190 - J Bacteriol. 2011 May;193(9):2158-67 – reference: 18617888 - EMBO Rep. 2008 Aug;9(8):735-41 – reference: 17558395 - Nat Cell Biol. 2007 Jul;9(7):797-803 – reference: 22017253 - Mol Microbiol. 2011 Dec;82(5):1277-90 – reference: 20971679 - Curr Opin Microbiol. 2011 Feb;14(1):9-15 – reference: 19201795 - J Bacteriol. 2009 Apr;191(8):2431-46 – reference: 21178498 - Virulence. 2010 Nov-Dec;1(6):535-40 – reference: 20961764 - Trends Microbiol. 2010 Dec;18(12):531-7 – reference: 17098922 - Appl Environ Microbiol. 2007 Jan;73(2):650-4 – reference: 22411981 - Philos Trans R Soc Lond B Biol Sci. 2012 Apr 19;367(1592):1102-11 – reference: 19624706 - Environ Microbiol. 2009 Dec;11(12):3018-28 – reference: 19251647 - Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4160-5 – reference: 21047256 - Annu Rev Genet. 2010;44:71-90 – reference: 22367545 - Nature. 2012 Mar 8;483(7388):182-6 – reference: 20638635 - Cell Host Microbe. 2010 Jul 22;8(1):2-6 – reference: 12542086 - Dis Aquat Organ. 2002 Nov 22;52(2):93-107 – reference: 21829382 - PLoS Genet. 2011 Jul;7(7):e1002205 – reference: 16458574 - Curr Opin Microbiol. 2006 Apr;9(2):201-6 – reference: 11932449 - Microbiology. 2002 Apr;148(Pt 4):1039-48 – reference: 22950014 - Microbiologyopen. 2012 Mar;1(1):71-82 – reference: 21949076 - J Bacteriol. 2011 Dec;193(23):6471-82 – reference: 19243444 - FEMS Microbiol Rev. 2009 Mar;33(2):279-94 – reference: 21953460 - J Biol Chem. 2011 Nov 11;286(45):39417-30 – reference: 21084635 - Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21128-33 – reference: 19426209 - Mol Microbiol. 2009 May;72(3):612-32 – reference: 19229296 - EMBO J. 2009 Apr 8;28(7):821-9 – reference: 18805985 - J Bacteriol. 2008 Nov;190(22):7523-31 – reference: 19602144 - Mol Microbiol. 2009 Aug;73(3):434-45 – reference: 17304251 - Nat Rev Microbiol. 2007 Mar;5(3):230-9 – reference: 17993530 - J Bacteriol. 2008 Jan;190(2):476-86 – reference: 8491699 - J Bacteriol. 1993 May;175(10):2793-8 – reference: 14597753 - J Clin Invest. 2003 Nov;112(9):1291-9 – reference: 2848245 - Proc Natl Acad Sci U S A. 1988 Dec;85(23):8919-23 – reference: 19756009 - Nat Rev Microbiol. 2009 Oct;7(10):703-14 – reference: 19131969 - EMBO J. 2009 Feb 18;28(4):315-25 – reference: 18047567 - Mol Microbiol. 2008 Jan;67(2):241-53 – reference: 19395482 - J Bacteriol. 2009 Jul;191(13):4316-29 – reference: 21873404 - Microbiology. 2011 Dec;157(Pt 12):3292-305 – reference: 19276114 - Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4067-8 – reference: 19284603 - BMC Genomics. 2009;10:104 – reference: 19946141 - Microbiol Mol Biol Rev. 2009 Dec;73(4):775-808 – reference: 19400797 - Mol Microbiol. 2009 Jun;72(5):1111-25 – reference: 20511495 - J Bacteriol. 2010 Aug;192(15):3850-60 – reference: 19686078 - Annu Rev Genet. 2009;43:197-222 – reference: 17873062 - Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15508-13 – reference: 12127983 - Biochem Biophys Res Commun. 2002 Jul 26;295(4):922-8 – reference: 4933423 - J Mol Biol. 1971 Jun 28;58(3):685-92 – reference: 16925558 - Mol Microbiol. 2006 Sep;61(5):1267-82 – reference: 20487285 - Mol Microbiol. 2010 Feb;75(4):886-99 – reference: 21361789 - Mol Plant Microbe Interact. 2011 Jul;24(7):751-7 – reference: 21298257 - Arch Microbiol. 2011 May;193(5):351-63 – reference: 19258189 - Best Pract Res Clin Gastroenterol. 2009;23(1):89-99 – reference: 21784934 - J Bacteriol. 2011 Oct;193(19):5510-3 – reference: 1356964 - J Bacteriol. 1992 Oct;174(19):6061-70 – reference: 20729192 - J Biol Chem. 2010 Nov 12;285(46):35988-98 – reference: 21776071 - Nature. 2011 Jul 21;475(7356):301-3 – reference: 20114026 - Cell Host Microbe. 2010 Jan 21;7(1):25-37 – reference: 19286133 - Cell Host Microbe. 2009 Mar 19;5(3):234-43 – reference: 19497948 - Microbiology. 2009 Sep;155(Pt 9):2845-55 – reference: 9457432 - Clin Microbiol Rev. 1998 Jan;11(1):142-201 – reference: 18289922 - Curr Opin Microbiol. 2008 Feb;11(1):3-8 – reference: 11807075 - J Bacteriol. 2002 Feb;184(4):1140-54 – reference: 8830233 - Mol Microbiol. 1996 Feb;19(3):409-16 – reference: 4933424 - J Mol Biol. 1971 Jun 28;58(3):693-709 – reference: 22120744 - Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1065-72 – reference: 15659669 - J Bacteriol. 2005 Feb;187(3):912-22 – reference: 18566662 - PLoS Pathog. 2008 Jun;4(6):e1000093 – reference: 16531068 - J Struct Biol. 2006 Oct;156(1):190-9 – reference: 16760520 - Am J Trop Med Hyg. 2006 Jun;74(6):1060-6 |
| SSID | ssj0004709 |
| Score | 2.5130858 |
| SecondaryResourceType | review_article |
| Snippet | The type VI secretion system (T6SS) is a complex and widespread gram-negative bacterial export pathway with the capacity to translocate protein effectors into... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 453 |
| SubjectTerms | Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Secretion Systems - genetics Gram-Negative Bacteria - genetics Gram-Negative Bacteria - metabolism Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Protein Binding Protein Multimerization |
| Title | Structure and regulation of the type VI secretion system |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22746332 |
| Volume | 66 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LSwMxEA5WUbyI77cE9CbR7m42uzlKUaygF9tSTyWb3UCRPmjrQX-9k8c-qFrUSyibZdn0m06_zGS-QegiDlXiUcUJD0RCKIMhDiUlWaAksHsmM6Uzuo9P7L5NH7pht8zgm-qSWXIlP76tK_kPqnANcNVVsn9AtngoXIDPgC-MgDCMv8L42Yi_5imAiW0r7xigJpQmvtppXk41NzQTVri5ykidwH5ZwjLol9pMRfylrw9Qu2CpLqnOyiiq1i6wGY0X3f9IvpZnEBtiCibgKh4mfVmgC6x99FbJQLhzxy76YI5x5NGHzHlMGpLAd6qxzqWyqk-kVg34q6-uihQTszji-VpPjAANYdaTVlAcDwyMPuyjWWCDootn54S086kaqsGWQvdI1YGdvIQ2qvM1dO7e63rBW2n5aPekua2IoSStTbTh9hL4xhrGFlrKhtto1XYXfd9BcWEeGMwDl-aBRwqDeWBtHrjTxIV5YGseu6h9d9tq3BPXKIMIRvmMhFwlKhJSKxUJn2fwBycDjwpYVBorYNyB8lPBKQOuFgimWCp0f5VUAbeWcJO_h5aHo2F2gHCsYGVJyJkSlEbCEx7cplQ9koH0wLcfon275N7YqqH08i_j6MeZY7Rems4JWlHw88tOgcvNkjODwidLQEmF |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Structure+and+regulation+of+the+type+VI+secretion+system&rft.jtitle=Annual+review+of+microbiology&rft.au=Silverman%2C+Julie+M&rft.au=Brunet%2C+Yannick+R&rft.au=Cascales%2C+Eric&rft.au=Mougous%2C+Joseph+D&rft.date=2012-01-01&rft.eissn=1545-3251&rft.volume=66&rft.spage=453&rft_id=info:doi/10.1146%2Fannurev-micro-121809-151619&rft_id=info%3Apmid%2F22746332&rft_id=info%3Apmid%2F22746332&rft.externalDocID=22746332 |