Overview of Community-Acquired Pneumonia and the Role of Inflammatory Mechanisms in the Immunopathogenesis of Severe Pneumococcal Disease

• Published in: Mediators of Inflammation Vol. 2013; no. 2013; pp. 681 - 698-161
• Main Authors: Steel, Helen C., Cockeran, Riana, Anderson, Ronald, Feldman, Charles
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2013; Hindawi Puplishing Corporation; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Wiley
• Subjects: Antibiotics; Biofilms; Community-Acquired Infections - drug therapy; Community-Acquired Infections - etiology; Community-Acquired Infections - immunology; Community-Acquired Infections - mortality; Cost of Illness; Drug Resistance, Bacterial; Health aspects; Humans; Inflammation - complications; Pneumonia, Bacterial - drug therapy; Pneumonia, Bacterial - etiology; Pneumonia, Bacterial - immunology; Pneumonia, Bacterial - mortality; Pneumonia, Pneumococcal - etiology; Polymorphism, Single Nucleotide; Review; Severity of Illness Index; Virulence (Microbiology)

Community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality among the infectious diseases. Despite the implementation of national pneumococcal polyvalent vaccine-based immunisation strategies targeted at high-risk groups, Streptococcus pneumoniae (the pneumococcus) remains...