Association between Faecalibacterium prausnitzii Reduction and Inflammatory Bowel Disease : A Meta-Analysis and Systematic Review of the Literature

Background. Laboratory data suggests a reduction of Faecalibacterium prausnitzii (F. prausnitzii) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients. Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relev...

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Published inGastroenterology research and practice Vol. 2014; no. 2014; pp. 1 - 7
Main Authors Cao, Yuan, Shen, Jun, Ran, Zhi Hua
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2014
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Wiley
Subjects
Health aspects
Inflammatory bowel disease
Inflammatory bowel diseases
Methods
Microbiota (Symbiotic organisms)
Review
Risk factors
Studies
Tumor necrosis factor-TNF
Online AccessGet full text

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Abstract Background. Laboratory data suggests a reduction of Faecalibacterium prausnitzii (F. prausnitzii) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients. Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relevant to the etiology and pathogenesis of IBD. Methods. Medline, EMBASE, Pubmed, and others. were searched by 2 independent reviewers. Of 48 abstracts reviewed, 11 studies met our inclusion criteria (subject N=1180). Meta-analysis was performed with Review Manager 5.2. Results. The bacterial count of F. prausnitzii in IBD patients was significantly lower (6.7888±1.8875) log10 CFU/g feces than healthy controls (7.5791±1.5812) log10 CFU/g feces; P<0.0001. The Standardization Mean Difference of F. prausnitzii in IBD patients was −0.94 (95% confidence interval [CI]: −1.07–−0.80). Subgroup analyses revealed a trend toward a greater effect for CD (SMD: −1.13, 95% CI: −1.32–−0.94) when compared to UC (SMD: −0.78, 95% CI: −0.97–−0.60). Conclusions. The abundance of F. prausnitzii was decreased in IBD patients compared with healthy controls. Furthermore, the reduction of F. prausnitzii and misbalance of the intestinal microbiota are particularly higher in CD patients with ileal involvement.
AbstractList Background. Laboratory data suggests a reduction of Faecalibacterium prausnitzii (F. prausnitzii) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients. Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relevant to the etiology and pathogenesis of IBD. Methods. Medline, EMBASE, Pubmed, and others. were searched by 2 independent reviewers. Of 48 abstracts reviewed, 11 studies met our inclusion criteria (subject N = 1180). Meta-analysis was performed with Review Manager 5.2. Results. The bacterial count of F. prausnitzii in IBD patients was significantly lower (6.7888 ± 1.8875) log10 CFU/g feces than healthy controls (7.5791 ± 1.5812) log10 CFU/g feces; P < 0.0001. The Standardization Mean Difference of F. prausnitzii in IBD patients was -0.94 (95% confidence interval [CI]: -1.07--0.80). Subgroup analyses revealed a trend toward a greater effect for CD (SMD: -1.13, 95% CI: -1.32--0.94) when compared to UC (SMD: -0.78, 95% CI: -0.97--0.60). Conclusions. The abundance of F. prausnitzii was decreased in IBD patients compared with healthy controls. Furthermore, the reduction of F. prausnitzii and misbalance of the intestinal microbiota are particularly higher in CD patients with ileal involvement.
Background . Laboratory data suggests a reduction of Faecalibacterium prausnitzii ( F. prausnitzii ) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients. Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relevant to the etiology and pathogenesis of IBD. Methods . Medline, EMBASE, Pubmed, and others. were searched by 2 independent reviewers. Of 48 abstracts reviewed, 11 studies met our inclusion criteria (subject N = 1180 ). Meta-analysis was performed with Review Manager 5.2. Results . The bacterial count of F. prausnitzii in IBD patients was significantly lower ( 6.7888 ± 1.8875 ) log10 CFU/g feces than healthy controls ( 7.5791 ± 1.5812 ) log10 CFU/g feces; P < 0.0001 . The Standardization Mean Difference of F. prausnitzii in IBD patients was −0.94 (95% confidence interval [CI]: −1.07–−0.80). Subgroup analyses revealed a trend toward a greater effect for CD (SMD: −1.13, 95% CI: −1.32–−0.94) when compared to UC (SMD: −0.78, 95% CI: −0.97–−0.60). Conclusions . The abundance of F. prausnitzii was decreased in IBD patients compared with healthy controls. Furthermore, the reduction of F. prausnitzii and misbalance of the intestinal microbiota are particularly higher in CD patients with ileal involvement.
Background. Laboratory data suggests a reduction of Faecalibacterium prausnitzii (F. prausnitzii) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients. Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relevant to the etiology and pathogenesis of IBD. Methods. Medline, EMBASE, Pubmed, and others. were searched by 2 independent reviewers. Of 48 abstracts reviewed, 11 studies met our inclusion criteria (subject N=1180). Meta-analysis was performed with Review Manager 5.2. Results. The bacterial count of F. prausnitzii in IBD patients was significantly lower (6.7888±1.8875) log10 CFU/g feces than healthy controls (7.5791±1.5812) log10 CFU/g feces; P<0.0001. The Standardization Mean Difference of F. prausnitzii in IBD patients was -0.94 (95% confidence interval [CI]: -1.07--0.80). Subgroup analyses revealed a trend toward a greater effect for CD (SMD: -1.13, 95% CI: -1.32--0.94) when compared to UC (SMD: -0.78, 95% CI: -0.97--0.60). Conclusions. The abundance of F. prausnitzii was decreased in IBD patients compared with healthy controls. Furthermore, the reduction of F. prausnitzii and misbalance of the intestinal microbiota are particularly higher in CD patients with ileal involvement.
Background. Laboratory data suggests a reduction of Faecalibacterium prausnitzii (F. prausnitzii) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients. Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relevant to the etiology and pathogenesis of IBD. Methods. Medline, EMBASE, Pubmed, and others. were searched by 2 independent reviewers. Of 48 abstracts reviewed, 11 studies met our inclusion criteria (subject N=1180). Meta-analysis was performed with Review Manager 5.2. Results. The bacterial count of F. prausnitzii in IBD patients was significantly lower (6.7888±1.8875) log10 CFU/g feces than healthy controls (7.5791±1.5812) log10 CFU/g feces; P<0.0001. The Standardization Mean Difference of F. prausnitzii in IBD patients was −0.94 (95% confidence interval [CI]: −1.07–−0.80). Subgroup analyses revealed a trend toward a greater effect for CD (SMD: −1.13, 95% CI: −1.32–−0.94) when compared to UC (SMD: −0.78, 95% CI: −0.97–−0.60). Conclusions. The abundance of F. prausnitzii was decreased in IBD patients compared with healthy controls. Furthermore, the reduction of F. prausnitzii and misbalance of the intestinal microbiota are particularly higher in CD patients with ileal involvement.
Background. Laboratory data suggests a reduction of Faecalibacterium prausnitzii (F. prausnitzii) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients. Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relevant to the etiology and pathogenesis of IBD. Methods. Medline, EMBASE, Pubmed, and others. were searched by 2 independent reviewers. Of 48 abstracts reviewed, 11 studies met our inclusion criteria (subject N = 1180). Meta-analysis was performed with Review Manager 5.2. Results. The bacterial count of F. prausnitzii in IBD patients was significantly lower (6.7888 ± 1.8875) log10 CFU/g feces than healthy controls (7.5791 ± 1.5812) log10 CFU/g feces; P < 0.0001. The Standardization Mean Difference of F. prausnitzii in IBD patients was -0.94 (95% confidence interval [CI]: -1.07--0.80). Subgroup analyses revealed a trend toward a greater effect for CD (SMD: -1.13, 95% CI: -1.32--0.94) when compared to UC (SMD: -0.78, 95% CI: -0.97--0.60). Conclusions. The abundance of F. prausnitzii was decreased in IBD patients compared with healthy controls. Furthermore, the reduction of F. prausnitzii and misbalance of the intestinal microbiota are particularly higher in CD patients with ileal involvement.Background. Laboratory data suggests a reduction of Faecalibacterium prausnitzii (F. prausnitzii) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients. Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relevant to the etiology and pathogenesis of IBD. Methods. Medline, EMBASE, Pubmed, and others. were searched by 2 independent reviewers. Of 48 abstracts reviewed, 11 studies met our inclusion criteria (subject N = 1180). Meta-analysis was performed with Review Manager 5.2. Results. The bacterial count of F. prausnitzii in IBD patients was significantly lower (6.7888 ± 1.8875) log10 CFU/g feces than healthy controls (7.5791 ± 1.5812) log10 CFU/g feces; P < 0.0001. The Standardization Mean Difference of F. prausnitzii in IBD patients was -0.94 (95% confidence interval [CI]: -1.07--0.80). Subgroup analyses revealed a trend toward a greater effect for CD (SMD: -1.13, 95% CI: -1.32--0.94) when compared to UC (SMD: -0.78, 95% CI: -0.97--0.60). Conclusions. The abundance of F. prausnitzii was decreased in IBD patients compared with healthy controls. Furthermore, the reduction of F. prausnitzii and misbalance of the intestinal microbiota are particularly higher in CD patients with ileal involvement.
Background . Laboratory data suggests a reduction of Faecalibacterium prausnitzii ( F. prausnitzii ) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients. Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relevant to the etiology and pathogenesis of IBD. Methods . Medline, EMBASE, Pubmed, and others. were searched by 2 independent reviewers. Of 48 abstracts reviewed, 11 studies met our inclusion criteria (subject N = 1180). Meta-analysis was performed with Review Manager 5.2. Results . The bacterial count of F. prausnitzii in IBD patients was significantly lower (6.7888 ± 1.8875) log10 CFU/g feces than healthy controls (7.5791 ± 1.5812) log10 CFU/g feces; P < 0.0001. The Standardization Mean Difference of F. prausnitzii in IBD patients was −0.94 (95% confidence interval [CI]: −1.07–−0.80). Subgroup analyses revealed a trend toward a greater effect for CD (SMD: −1.13, 95% CI: −1.32–−0.94) when compared to UC (SMD: −0.78, 95% CI: −0.97–−0.60). Conclusions . The abundance of F. prausnitzii was decreased in IBD patients compared with healthy controls. Furthermore, the reduction of F. prausnitzii and misbalance of the intestinal microbiota are particularly higher in CD patients with ileal involvement.
Audience Academic
Author Shen, Jun
Ran, Zhi Hua
Cao, Yuan
AuthorAffiliation Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institution of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center, Shanghai 200127, China
AuthorAffiliation_xml – name: Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institution of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center, Shanghai 200127, China
Author_xml – sequence: 1
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– sequence: 2
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– sequence: 3
  fullname: Ran, Zhi Hua
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24799893$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1002/ibd.20903
10.1038/ajg.2012.335
10.1159/000228558
10.1073/pnas.0804812105
10.1038/nature11582
10.1002/ibd.20330
10.1016/S0016-5085(11)60576-3
10.1016/j.mib.2013.06.003
10.1111/j.1574-6941.2011.01252.x
10.1007/s00535-012-0605-0
10.33073/pjm-2013-013
10.1111/jgh.12153
10.1038/nature09944
10.1128/AEM.70.10.5810-5817.2004
10.1002/ibd.21923
10.1128/JCM.01500-13
10.1111/j.1365-2567.2012.03572.x
10.1002/ibd.21864
10.1017/S0007114510001030
10.1111/j.1574-6968.2009.01514.x
10.1097/01.MIB.0000435759.05577.12
10.1002/ibd.21116
10.1111/apt.12365
10.1111/jgh.12073
10.1016/j.crohns.2013.04.002
10.1136/gutjnl-2013-304833
10.1002/ibd.20783
10.1111/apt.12404
10.1002/ibd.21436
10.1097/QCO.0b013e32832a8a5d
10.1186/1471-2180-11-7
10.1111/j.1574-6968.2010.02057.x
10.1097/SLA.0b013e3181e3dc8b
10.1038/ajg.2013.257
10.1093/jac/dkq345
10.1097/MCG.0b013e31822fecfe
10.1053/j.gastro.2011.01.054
10.1097/01.mib.0000235828.09305.0c
10.1007/s10620-006-9461-1
10.1136/gut.2010.223263
10.1128/AEM.71.12.7724-7736.2005
ContentType Journal Article
Contributor Shen, Jun
Ran, Zhi Hua
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Copyright Copyright © 2014 Yuan Cao et al.
COPYRIGHT 2014 John Wiley & Sons, Inc.
Copyright © 2014 Yuan Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2014 Yuan Cao et al. 2014
Copyright_xml – notice: Copyright © 2014 Yuan Cao et al.
– notice: COPYRIGHT 2014 John Wiley & Sons, Inc.
– notice: Copyright © 2014 Yuan Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2014 Yuan Cao et al. 2014
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References (33) 2013; 108
(36) 2005; 71
(21) 2013; 28
(20) 2009; 15
(12) 2013; 38
(18) 2009; 15
(31) 2010; 65
(34) 2010; 252
(5) 2011; 473
(26) 2008; 105
(39) 2012; 136
(38) 2011; 45
(32) 2012; 18
(27) 2013; 7
(37) 2004; 70
(13) 2008; 14
(24) 2012; 107
(28) 2007; 52
(8) 2013
(30) 2013; 38
(41) 2013; 19
(19) 2012; 47
(10) 2011; 140
(35) 2009; 27
(2) 2012; 491
(6) 2009; 294
(16) 2013
(9) 2012; 18
(25) 2013; 28
(7) 2009; 22
(1) 2006; 12
(23) 2013; 16
(15) 2011; 60
(22) 2013; 62
(11) 2010; 16
(14) 2012; 79
(29) 2011; 17
(3) 2011; 140
(17) 2010; 310
(40) 2010; 104
(4) 2011; 11
22
23
24
25
26
27
(13) 2013; 62
28
29
30
31
10
32
11
33
34
12
35
14
36
15
37
16
38
17
39
18
19
1
2
3
4
5
6
7
8
9
40
41
20
21
20562611 - Ann Surg. 2010 Jul;252(1):90-8
22348589 - Immunology. 2012 Jun;136(2):115-22
19786749 - Dig Dis. 2009;27(3):252-8
19235886 - Inflamm Bowel Dis. 2009 Aug;15(8):1183-9
21992950 - J Clin Gastroenterol. 2011 Nov;45 Suppl:S120-7
17119388 - Inflamm Bowel Dis. 2006 Dec;12(12):1136-45
21530738 - Gastroenterology. 2011 May;140(6):1720-28
22092917 - FEMS Microbiol Ecol. 2012 Mar;79(3):685-96
18050295 - Inflamm Bowel Dis. 2008 Feb;14(2):147-61
22576027 - J Gastroenterol. 2012 Dec;47(12):1298-307
19352175 - Curr Opin Infect Dis. 2009 Jun;22(3):292-301
19760778 - Inflamm Bowel Dis. 2010 Jun;16(6):1077-84
23216550 - J Gastroenterol Hepatol. 2013 Apr;28(4):613-9
21209126 - Gut. 2011 May;60(5):631-7
23725320 - Aliment Pharmacol Ther. 2013 Jul;38(2):151-61
21219646 - BMC Microbiol. 2011 Jan 10;11:7
18936492 - Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
20722058 - Inflamm Bowel Dis. 2011 Jan;17(1):185-92
15466518 - Appl Environ Microbiol. 2004 Oct;70(10):5810-7
23128233 - Nature. 2012 Nov 1;491(7422):119-24
20695899 - FEMS Microbiol Lett. 2010 Sep 1;310(2):138-44
19222573 - FEMS Microbiol Lett. 2009 May;294(1):1-8
23831042 - Curr Opin Microbiol. 2013 Jun;16(3):255-61
17265126 - Dig Dis Sci. 2007 Mar;52(3):620-7
24240708 - Inflamm Bowel Dis. 2013 Dec;19(13):2906-18
16332745 - Appl Environ Microbiol. 2005 Dec;71(12):7724-36
20852272 - J Antimicrob Chemother. 2010 Dec;65(12):2556-65
20346190 - Br J Nutr. 2010 Sep;104(5):693-700
24478468 - J Clin Microbiol. 2014 Feb;52(2):398-406
23937459 - Aliment Pharmacol Ther. 2013 Sep;38(5):551
24021287 - Gut. 2014 Aug;63(8):1275-83
21508958 - Nature. 2011 May 12;473(7346):174-80
24060759 - Am J Gastroenterol. 2013 Oct;108(10):1620-30
22102318 - Inflamm Bowel Dis. 2012 Jun;18(6):1092-100
23614339 - J Gastroenterol Hepatol. 2013 May;28(5):757-9
23829084 - Pol J Microbiol. 2013;62(1):91-5
19023901 - Inflamm Bowel Dis. 2009 May;15(5):653-60
22113988 - Inflamm Bowel Dis. 2012 Sep;18(9):1663-71
23044767 - Am J Gastroenterol. 2012 Dec;107(12):1913-22
23643066 - J Crohns Colitis. 2013 Dec;7(11):e558-68
References_xml – volume: 15
  start-page: 653
  issue: 5
  year: 2009
  end-page: 660
  ident: 20
  article-title: Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease
– volume: 16
  start-page: 255
  issue: 3
  year: 2013
  end-page: 261
  ident: 23
  article-title: Faecalibacterium prausnitzii and human intestinal health
– volume: 140
  issue: 5
  year: 2011
  ident: 10
  article-title: Association of Faecalibacterium prausnitzii and disease activity in ulcerative colitis
– volume: 108
  start-page: 1620
  issue: 10
  year: 2013
  end-page: 1630
  ident: 33
  article-title: Temporal bacterial community dynamics vary among ulcerative colitis patients after fecal microbiota transplantation
– volume: 28
  start-page: 757
  issue: 5
  year: 2013
  end-page: 759
  ident: 25
  article-title: The more the merrier: Faecalibacterium prausnitzii in Crohn’s disease
– volume: 105
  start-page: 16731
  issue: 43
  year: 2008
  end-page: 16736
  ident: 26
  article-title: Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
– volume: 38
  start-page: 551
  issue: 5
  year: 2013
  ident: 30
  article-title: Commentary: is Faecalibacterium prausnitzii a potential treatment for maintaining remission in ulcerative colitis?
– volume: 252
  start-page: 90
  issue: 1
  year: 2010
  end-page: 98
  ident: 34
  article-title: The bacteriology of pouchitis: a molecular phylogenetic analysis using 16s rRNA gene cloning and sequencing
– volume: 310
  start-page: 138
  issue: 2
  year: 2010
  end-page: 144
  ident: 17
  article-title: Is the abundance of Faecalibacterium prausnitzii relevant to Crohn's disease?
– volume: 17
  start-page: 185
  issue: 1
  year: 2011
  end-page: 192
  ident: 29
  article-title: Highlighting new phylogenetic specificities of Crohn's disease microbiota
– volume: 136
  start-page: 115
  issue: 2
  year: 2012
  end-page: 122
  ident: 39
  article-title: Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers
– volume: 60
  start-page: 631
  issue: 5
  year: 2011
  end-page: 637
  ident: 15
  article-title: Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
– volume: 18
  start-page: 1092
  issue: 6
  year: 2012
  end-page: 1100
  ident: 32
  article-title: Smokers with active Crohn’s disease have a clinically relevant dysbiosis of the gastrointestinal microbiota
– volume: 28
  start-page: 613
  issue: 4
  year: 2013
  end-page: 619
  ident: 21
  article-title: Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn’s disease
– volume: 15
  start-page: 1183
  issue: 8
  year: 2009
  end-page: 1189
  ident: 18
  article-title: Low counts of Faecalibacterium prausnitzii in colitis microbiota
– volume: 19
  start-page: 2906
  issue: 13
  year: 2013
  end-page: 2918
  ident: 41
  article-title: Impact of ethnicity, geography, and disease on the microbiota in health and inflammatory bowel disease
– volume: 107
  start-page: 1913
  issue: 12
  year: 2012
  end-page: 1922
  ident: 24
  article-title: Microbiota of Pediatric IBD: increased Faecalibacterium prausnitzii and reduced bacterial diversity in Crohn's but not in ulcerative colitis
– volume: 140
  start-page: 1720
  issue: 6
  year: 2011
  end-page: 1728
  ident: 3
  article-title: The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases
– volume: 491
  start-page: 119
  issue: 7422
  year: 2012
  end-page: 124
  ident: 2
  article-title: Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
– volume: 294
  start-page: 1
  issue: 1
  year: 2009
  end-page: 8
  ident: 6
  article-title: Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine
– volume: 47
  start-page: 1298
  issue: 12
  year: 2012
  end-page: 1307
  ident: 19
  article-title: Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn’s disease
– volume: 45
  start-page: S120
  year: 2011
  end-page: S127
  ident: 38
  article-title: Fermentation in the human large intestine: its physiologic consequences and the potential contribution of prebiotics
– volume: 7
  start-page: e558
  issue: 11
  year: 2013
  end-page: e568
  ident: 27
  article-title: Faecalibacterium prausnitzii upregulates regulatory T cells and anti-inflammatory cytokines in treating TNBS-induced colitis
– volume: 79
  start-page: 685
  issue: 3
  year: 2012
  end-page: 696
  ident: 14
  article-title: Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an dynamic gut model with mucin environment
– volume: 38
  start-page: 151
  issue: 2
  year: 2013
  end-page: 161
  ident: 12
  article-title: Colonisation by Faecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis
– volume: 62
  start-page: 91
  issue: 1
  year: 2013
  end-page: 95
  ident: 22
  article-title: Faecalibacterium prausnitzii and Crohn’s disease—is there any connection?
– volume: 52
  start-page: 620
  issue: 3
  year: 2007
  end-page: 627
  ident: 28
  article-title: High proportions of proinflammatory bacteria on the colonic mucosa in a young patient with ulcerative colitis as revealed by cloning and sequencing of 16S rRNA genes
– volume: 65
  start-page: 2556
  issue: 12
  year: 2010
  end-page: 2565
  ident: 31
  article-title: Rifaximin modulates the colonic microbiota of patients with Crohn's disease: an approach using a continuous culture colonic model system
– volume: 18
  start-page: 1663
  issue: 9
  year: 2012
  end-page: 1671
  ident: 9
  article-title: Common biostructure of the colonic microbiota in neuroendocrine tumors and Crohn's disease and the effect of therapy
– volume: 16
  start-page: 1077
  issue: 6
  year: 2010
  end-page: 1084
  ident: 11
  article-title: Association between Helicobacter pylori infection and inflammatory bowel disease: a meta-analysis and systematic review of the literature
– volume: 104
  start-page: 693
  issue: 5
  year: 2010
  end-page: 700
  ident: 40
  article-title: Association between Faecalibacterium prausnitzii and dietary fibre in colonic fermentation in healthy human subjects
– year: 2013
  ident: 8
  article-title: A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis
– volume: 71
  start-page: 7724
  issue: 12
  year: 2005
  end-page: 7736
  ident: 36
  article-title: At least 1 in 20 16S rRNA sequence records currently held in public repositories is estimated to contain substantial anomalies
– year: 2013
  ident: 16
  article-title: Increased proportion of Bifidobacterium and the Lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease
– volume: 11
  year: 2011
  ident: 4
  article-title: High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease
– volume: 22
  start-page: 292
  issue: 3
  year: 2009
  end-page: 301
  ident: 7
  article-title: Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases
– volume: 70
  start-page: 5810
  issue: 10
  year: 2004
  end-page: 5817
  ident: 37
  article-title: Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product
– volume: 14
  start-page: 147
  issue: 2
  year: 2008
  end-page: 161
  ident: 13
  article-title: Active Crohn's disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora
– volume: 473
  start-page: 174
  issue: 7346
  year: 2011
  end-page: 180
  ident: 5
  article-title: Enterotypes of the human gut microbioma
– volume: 12
  start-page: 1136
  issue: 12
  year: 2006
  end-page: 1145
  ident: 1
  article-title: Abnormal microbiota composition in the ileocolonic mucosa of Crohn's disease patients as revealed by polymerase chain reaction-denaturing gradient gel electrophoresis
– volume: 27
  start-page: 252
  issue: 3
  year: 2009
  end-page: 258
  ident: 35
  article-title: The microbiota in inflammatory bowel disease in different age groups
– ident: 33
  doi: 10.1002/ibd.20903
– ident: 15
  doi: 10.1038/ajg.2012.335
– ident: 26
  doi: 10.1159/000228558
– ident: 17
  doi: 10.1073/pnas.0804812105
– ident: 2
  doi: 10.1038/nature11582
– ident: 27
  doi: 10.1002/ibd.20330
– ident: 10
  doi: 10.1016/S0016-5085(11)60576-3
– ident: 14
  doi: 10.1016/j.mib.2013.06.003
– ident: 29
  doi: 10.1111/j.1574-6941.2011.01252.x
– ident: 34
  doi: 10.1007/s00535-012-0605-0
– volume: 62
  start-page: 91
  issue: 1
  year: 2013
  ident: 13
  publication-title: Polish Journal of Microbiology
  doi: 10.33073/pjm-2013-013
– ident: 16
  doi: 10.1111/jgh.12153
– ident: 5
  doi: 10.1038/nature09944
– ident: 37
  doi: 10.1128/AEM.70.10.5810-5817.2004
– ident: 9
  doi: 10.1002/ibd.21923
– ident: 31
  doi: 10.1128/JCM.01500-13
– ident: 39
  doi: 10.1111/j.1365-2567.2012.03572.x
– ident: 23
  doi: 10.1002/ibd.21864
– ident: 40
  doi: 10.1017/S0007114510001030
– ident: 6
  doi: 10.1111/j.1574-6968.2009.01514.x
– ident: 41
  doi: 10.1097/01.MIB.0000435759.05577.12
– ident: 11
  doi: 10.1002/ibd.21116
– ident: 28
  doi: 10.1111/apt.12365
– ident: 12
  doi: 10.1111/jgh.12073
– ident: 18
  doi: 10.1016/j.crohns.2013.04.002
– ident: 8
  doi: 10.1136/gutjnl-2013-304833
– ident: 35
  doi: 10.1002/ibd.20783
– ident: 21
  doi: 10.1111/apt.12404
– ident: 20
  doi: 10.1002/ibd.21436
– ident: 7
  doi: 10.1097/QCO.0b013e32832a8a5d
– ident: 4
  doi: 10.1186/1471-2180-11-7
– ident: 32
  doi: 10.1111/j.1574-6968.2010.02057.x
– ident: 25
  doi: 10.1097/SLA.0b013e3181e3dc8b
– ident: 24
  doi: 10.1038/ajg.2013.257
– ident: 22
  doi: 10.1093/jac/dkq345
– ident: 38
  doi: 10.1097/MCG.0b013e31822fecfe
– ident: 3
  doi: 10.1053/j.gastro.2011.01.054
– ident: 1
  doi: 10.1097/01.mib.0000235828.09305.0c
– ident: 19
  doi: 10.1007/s10620-006-9461-1
– ident: 30
  doi: 10.1136/gut.2010.223263
– ident: 36
  doi: 10.1128/AEM.71.12.7724-7736.2005
– reference: 23829084 - Pol J Microbiol. 2013;62(1):91-5
– reference: 23128233 - Nature. 2012 Nov 1;491(7422):119-24
– reference: 22576027 - J Gastroenterol. 2012 Dec;47(12):1298-307
– reference: 20722058 - Inflamm Bowel Dis. 2011 Jan;17(1):185-92
– reference: 17119388 - Inflamm Bowel Dis. 2006 Dec;12(12):1136-45
– reference: 22092917 - FEMS Microbiol Ecol. 2012 Mar;79(3):685-96
– reference: 24060759 - Am J Gastroenterol. 2013 Oct;108(10):1620-30
– reference: 17265126 - Dig Dis Sci. 2007 Mar;52(3):620-7
– reference: 22113988 - Inflamm Bowel Dis. 2012 Sep;18(9):1663-71
– reference: 24478468 - J Clin Microbiol. 2014 Feb;52(2):398-406
– reference: 19235886 - Inflamm Bowel Dis. 2009 Aug;15(8):1183-9
– reference: 23937459 - Aliment Pharmacol Ther. 2013 Sep;38(5):551
– reference: 19760778 - Inflamm Bowel Dis. 2010 Jun;16(6):1077-84
– reference: 21209126 - Gut. 2011 May;60(5):631-7
– reference: 23831042 - Curr Opin Microbiol. 2013 Jun;16(3):255-61
– reference: 15466518 - Appl Environ Microbiol. 2004 Oct;70(10):5810-7
– reference: 20346190 - Br J Nutr. 2010 Sep;104(5):693-700
– reference: 23614339 - J Gastroenterol Hepatol. 2013 May;28(5):757-9
– reference: 18936492 - Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
– reference: 19023901 - Inflamm Bowel Dis. 2009 May;15(5):653-60
– reference: 19222573 - FEMS Microbiol Lett. 2009 May;294(1):1-8
– reference: 21992950 - J Clin Gastroenterol. 2011 Nov;45 Suppl:S120-7
– reference: 20695899 - FEMS Microbiol Lett. 2010 Sep 1;310(2):138-44
– reference: 23216550 - J Gastroenterol Hepatol. 2013 Apr;28(4):613-9
– reference: 23725320 - Aliment Pharmacol Ther. 2013 Jul;38(2):151-61
– reference: 23044767 - Am J Gastroenterol. 2012 Dec;107(12):1913-22
– reference: 22102318 - Inflamm Bowel Dis. 2012 Jun;18(6):1092-100
– reference: 23643066 - J Crohns Colitis. 2013 Dec;7(11):e558-68
– reference: 18050295 - Inflamm Bowel Dis. 2008 Feb;14(2):147-61
– reference: 21508958 - Nature. 2011 May 12;473(7346):174-80
– reference: 21219646 - BMC Microbiol. 2011 Jan 10;11:7
– reference: 21530738 - Gastroenterology. 2011 May;140(6):1720-28
– reference: 16332745 - Appl Environ Microbiol. 2005 Dec;71(12):7724-36
– reference: 19352175 - Curr Opin Infect Dis. 2009 Jun;22(3):292-301
– reference: 24240708 - Inflamm Bowel Dis. 2013 Dec;19(13):2906-18
– reference: 22348589 - Immunology. 2012 Jun;136(2):115-22
– reference: 19786749 - Dig Dis. 2009;27(3):252-8
– reference: 20562611 - Ann Surg. 2010 Jul;252(1):90-8
– reference: 20852272 - J Antimicrob Chemother. 2010 Dec;65(12):2556-65
– reference: 24021287 - Gut. 2014 Aug;63(8):1275-83
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Snippet Background. Laboratory data suggests a reduction of Faecalibacterium prausnitzii (F. prausnitzii) is confirmed both in fecal samples in inflammatory bowel...
Background . Laboratory data suggests a reduction of Faecalibacterium prausnitzii ( F. prausnitzii ) is confirmed both in fecal samples in inflammatory bowel...
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SubjectTerms Health aspects
Inflammatory bowel disease
Inflammatory bowel diseases
Methods
Microbiota (Symbiotic organisms)
Review
Risk factors
Studies
Tumor necrosis factor-TNF
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Title Association between Faecalibacterium prausnitzii Reduction and Inflammatory Bowel Disease : A Meta-Analysis and Systematic Review of the Literature
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https://dx.doi.org/10.1155/2014/872725
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Volume 2014
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