Protein secretion in gram-negative bacteria via the autotransporter pathway

• Published in: Annual review of microbiology Vol. 61; p. 89
• Main Authors: Dautin, Nathalie, Bernstein, Harris D
• Format: Journal Article
• Language: English
• Published: United States 01.01.2007
• Subjects: Amino Acid Sequence; Bacterial Outer Membrane Proteins - metabolism; Bacterial Proteins - chemistry; Bacterial Proteins - physiology; Bacterial Proteins - secretion; Cell Membrane - metabolism; Glycosylation; Gram-Negative Bacteria - metabolism; Membrane Transport Proteins - physiology; Molecular Sequence Data; Periplasm - metabolism; Protein Structure, Tertiary; Protein Transport

Autotransporters are a large and diverse superfamily of proteins produced by pathogenic gram-negative bacteria that are composed of an N-terminal passenger domain, which typically harbors a virulence function, and a C-terminal beta domain. It has long been known that the beta domain anchors the prot...