Protein secretion in gram-negative bacteria via the autotransporter pathway
Autotransporters are a large and diverse superfamily of proteins produced by pathogenic gram-negative bacteria that are composed of an N-terminal passenger domain, which typically harbors a virulence function, and a C-terminal beta domain. It has long been known that the beta domain anchors the prot...
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Published in | Annual review of microbiology Vol. 61; p. 89 |
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Main Authors | , |
Format | Journal Article |
Language | English |
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United States
01.01.2007
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Abstract | Autotransporters are a large and diverse superfamily of proteins produced by pathogenic gram-negative bacteria that are composed of an N-terminal passenger domain, which typically harbors a virulence function, and a C-terminal beta domain. It has long been known that the beta domain anchors the protein to the outer membrane and facilitates transport of the passenger domain into the extracellular space. Despite the apparent simplicity of the autotransporter pathway, several aspects of autotransporter biogenesis remain poorly understood, most notably the mechanism by which the passenger domain is translocated across the outer membrane. Here we review recent evidence that the enormous sequence diversity of both passenger and beta domains belies a remarkable conservation of structure. We also discuss insights into each stage of autotransporter biogenesis that have emerged from recent structural, biochemical, and imaging studies. |
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AbstractList | Autotransporters are a large and diverse superfamily of proteins produced by pathogenic gram-negative bacteria that are composed of an N-terminal passenger domain, which typically harbors a virulence function, and a C-terminal beta domain. It has long been known that the beta domain anchors the protein to the outer membrane and facilitates transport of the passenger domain into the extracellular space. Despite the apparent simplicity of the autotransporter pathway, several aspects of autotransporter biogenesis remain poorly understood, most notably the mechanism by which the passenger domain is translocated across the outer membrane. Here we review recent evidence that the enormous sequence diversity of both passenger and beta domains belies a remarkable conservation of structure. We also discuss insights into each stage of autotransporter biogenesis that have emerged from recent structural, biochemical, and imaging studies. |
Author | Dautin, Nathalie Bernstein, Harris D |
Author_xml | – sequence: 1 givenname: Nathalie surname: Dautin fullname: Dautin, Nathalie email: nathalied@niddk.nih.gov organization: Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0538, USA. nathalied@niddk.nih.gov – sequence: 2 givenname: Harris D surname: Bernstein fullname: Bernstein, Harris D |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17506669$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Amino Acid Sequence Bacterial Outer Membrane Proteins - metabolism Bacterial Proteins - chemistry Bacterial Proteins - physiology Bacterial Proteins - secretion Cell Membrane - metabolism Glycosylation Gram-Negative Bacteria - metabolism Membrane Transport Proteins - physiology Molecular Sequence Data Periplasm - metabolism Protein Structure, Tertiary Protein Transport |
Title | Protein secretion in gram-negative bacteria via the autotransporter pathway |
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