Pathological Basis for Deficient Excitatory Drive to Cortical Parvalbumin Interneurons in Schizophrenia

• Published in: The American journal of psychiatry Vol. 173; no. 11; pp. 1131 - 1139
• Main Authors: Chung, Daniel W, Fish, Kenneth N, Lewis, David A
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.11.2016
• Subjects: Adult; Animals; Antipsychotic Agents - pharmacology; Calbindin 2 - metabolism; Case-Control Studies; Disks Large Homolog 4 Protein; Female; Fluorescence; Glutamate Decarboxylase - biosynthesis; Humans; Immunohistochemistry; Interneurons - drug effects; Interneurons - metabolism; Intracellular Signaling Peptides and Proteins - metabolism; Macaca fascicularis; Male; Membrane Proteins - metabolism; Middle Aged; Neurons; Parvalbumins - drug effects; Parvalbumins - metabolism; Pathology; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Schizophrenia; Schizophrenia - metabolism; Schizophrenia - pathology; Vesicular Glutamate Transport Protein 1 - metabolism

Objective:Deficient excitatory drive to parvalbumin-containing cortical interneurons is proposed as a key neural substrate for altered gamma oscillations and cognitive dysfunction in schizophrenia. However, a pathological entity producing such a deficit has not been identified. The authors tested th...