Characterization of Genetic Elements Carrying mcr-1 Gene in Escherichia coli from the Community and Hospital Settings in Vietnam

• Published in: Microbiology spectrum Vol. 10; no. 1; p. e0135621
• Main Authors: Vu Thi Ngoc, Bich, Le Viet, Thanh, Nguyen Thi Tuyet, Mai, Nguyen Thi Hong, Thuong, Nguyen Thi Ngoc, Diep, Le Van, Duyet, Chu Thi, Loan, Tran Huy, Hoang, Penders, John, Wertheim, Heiman, van Doorn, H Rogier
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 23.02.2022
• Subjects: Anti-Bacterial Agents - pharmacology; Antimicrobial Chemotherapy; antimicrobial resistance; Colistin - pharmacology; colistin resistance; Drug Resistance, Bacterial; Escherichia coli - classification; Escherichia coli - drug effects; Escherichia coli - genetics; Escherichia coli - metabolism; Escherichia coli Infections - microbiology; Escherichia coli Proteins - genetics; Feces - microbiology; Hospitals - statistics & numerical data; Humans; Interspersed Repetitive Sequences; mcr-1 transmission; Microbial Sensitivity Tests; multireplicon plasmid; One health; Phylogeny; plasmid harboring mcr-1; Plasmids - genetics; Plasmids - metabolism; Research Article; Vietnam; Vietnam; plasmid harboring mcr-1; One health; multireplicon plasmid; mcr-1 transmission; antimicrobial resistance; Escherichia coli; colistin resistance

Colistin is widely used in agriculture and aquaculture as prophylaxis, particularly in Asia. Recently, and other mobilizable genes conferring colistin resistance have spread globally in community and hospital populations. Characterizing mobile genetic elements and host genetic background is importan...