Mechanisms of Disease: Pemphigus and Bullous Pemphigoid

• Published in: Annual review of pathology Vol. 11; no. 1; pp. 175 - 197
• Main Authors: Hammers, Christoph M, Stanley, John R
• Format: Journal Article
• Language: English
• Published: United States Annual Reviews 23.05.2016
• Subjects: Animals; autoantibody; autoimmune; blistering; Humans; Pemphigoid, Bullous - immunology; Pemphigoid, Bullous - pathology; Pemphigus - immunology; Pemphigus - pathology; skin; skin; autoantibody; autoimmune; blistering

Pemphigus and bullous pemphigoid are autoantibody-mediated blistering skin diseases. In pemphigus, keratinocytes in epidermis and mucous membranes lose cell-cell adhesion, and in pemphigoid, the basal keratinocytes lose adhesion to the basement membrane. Pemphigus lesions are mediated directly by th...