Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics

High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as well as various antiatherogenic, antioxidant, and anti-inflamma...

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Published inCholesterol Vol. 2015; no. 2015; pp. c1 - 22
Main Authors Salazar, Juan, Chavez-Castillo, Mervin, Ramos, Eduardo, Rojas, Joselyn, Bermudez, Valmore, Olivar, Luis Carlos
Format Journal Article
LanguageEnglish
Published United States Hindawi Limiteds 01.01.2015
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Cholesterol
Fatty acids
Genetic aspects
High density lipoproteins
Lipids
Low density lipoprotein
Physiological aspects
Prevention
Proteomics
Review
Risk factors
Venezuela
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Abstract High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as well as various antiatherogenic, antioxidant, and anti-inflammatory properties. Nevertheless, observations of hereditary syndromes featuring scant HDL-C concentration in absence of premature atherosclerotic disease suggest HDL-C levels may not be the best predictor of cardiovascular disease. Indeed, the beneficial effects of HDL may not depend solely on their concentration, but also on their quality. Distinct subfractions of this lipoprotein appear to be constituted by specific protein-lipid conglomerates necessary for different physiologic and pathophysiologic functions. However, in a chronic inflammatory microenvironment, diverse components of the HDL proteome and lipid core suffer alterations, which propel a shift towards a dysfunctional state, where HDL-C becomes proatherogenic, prooxidant, and proinflammatory. This heterogeneity highlights the need for further specialized molecular studies in this aspect, in order to achieve a better understanding of this dysfunctional state; with an emphasis on the potential role for proteomics and lipidomics as valuable methods in the search of novel therapeutic approaches for cardiovascular disease.
AbstractList High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as well as various antiatherogenic, antioxidant, and anti-inflammatory properties. Nevertheless, observations of hereditary syndromes featuring scant HDL-C concentration in absence of premature atherosclerotic disease suggest HDL-C levels may not be the best predictor of cardiovascular disease. Indeed, the beneficial effects of HDL may not depend solely on their concentration, but also on their quality. Distinct subfractions of this lipoprotein appear to be constituted by specific protein-lipid conglomerates necessary for different physiologic and pathophysiologic functions. However, in a chronic inflammatory microenvironment, diverse components of the HDL proteome and lipid core suffer alterations, which propel a shift towards a dysfunctional state, where HDL-C becomes proatherogenic, prooxidant, and proinflammatory. This heterogeneity highlights the need for further specialized molecular studies in this aspect, in order to achieve a better understanding of this dysfunctional state; with an emphasis on the potential role for proteomics and lipidomics as valuable methods in the search of novel therapeutic approaches for cardiovascular disease.
Audience Academic
Author Joselyn Rojas
Luis Carlos Olivar
Juan Salazar
Eduardo Ramos,Mervin Chávez-Castillo
Valmore Bermúdez
AuthorAffiliation Endocrine-Metabolic Research Center, “Dr. Félix Gómez,” Faculty of Medicine, University of Zulia, Zulia State, Maracaibo 4004, Venezuela
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/26634153$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
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COPYRIGHT 2015 John Wiley & Sons, Inc.
Copyright © 2015 Juan Salazar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2015 Juan Salazar et al. 2015
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PublicationDateYYYYMMDD 2015-01-01
PublicationDate_xml – month: 01
  year: 2015
  text: 2015-01-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: New York
PublicationTitle Cholesterol
PublicationTitleAlternate Cholesterol
PublicationYear 2015
Publisher Hindawi Limiteds
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Hindawi Limited
Publisher_xml – name: Hindawi Limiteds
– name: Hindawi Publishing Corporation
– name: John Wiley & Sons, Inc
– name: Hindawi Limited
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Snippet High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse...
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SubjectTerms Cardiovascular disease
Cardiovascular diseases
Care and treatment
Cholesterol
Fatty acids
Genetic aspects
High density lipoproteins
Lipids
Low density lipoprotein
Physiological aspects
Prevention
Proteomics
Review
Risk factors
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Title Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
URI https://www.airitilibrary.com/Article/Detail/P20151112003-201512-201608170017-201608170017-c1-22
https://dx.doi.org/10.1155/2015/296417
https://www.ncbi.nlm.nih.gov/pubmed/26634153
https://www.proquest.com/docview/1735291863
https://search.proquest.com/docview/1749599918
https://pubmed.ncbi.nlm.nih.gov/PMC4655037
Volume 2015
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