Comparison of mutations in human parainfluenza viruses during passage in primary human bronchial/tracheal epithelial air-liquid interface cultures and cell lines

• Published in: Microbiology Spectrum Vol. 12; no. 9; p. e0116424
• Main Authors: Sugimoto, Satoko, Kawase, Miyuki, Suwa, Reiko, Kume, Yohei, Chishiki, Mina, Ono, Takashi, Okabe, Hisao, Norito, Sakurako, Hanaki, Ken-Ichi, Hosoya, Mitsuaki, Hashimoto, Koichi, Shirato, Kazuya
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 03.09.2024
• Subjects: air-liquid interface culture; cell culture adaptation; hemagglutinin neuraminidase protein; human parainfluenza virus; Microbiology; QR1-502; quasispecies; Research Article; Virology; air-liquid interface culture; cell culture adaptation; hemagglutinin neuraminidase protein; human parainfluenza virus; quasispecies

Adaptation of viruses to cultured cells can increase the risk of misinterpretation in virological characterization of clinical isolates. In human parainfluenza virus (HPIV) 3, it has been reported that the human airway epithelial and lung organoid models are preferable for the study of viral charact...