Gut Microbiota Offers Universal Biomarkers across Ethnicity in Inflammatory Bowel Disease Diagnosis and Infliximab Response Prediction

• Published in: mSystems Vol. 3; no. 1
• Main Authors: Zhou, Youlian, Xu, Zhenjiang Zech, He, Yan, Yang, Yunsheng, Liu, Le, Lin, Qianyun, Nie, Yuqiang, Li, Mingsong, Zhi, Fachao, Liu, Side, Amir, Amnon, González, Antonio, Tripathi, Anupriya, Chen, Minhu, Wu, Gary D., Knight, Rob, Zhou, Hongwei, Chen, Ye
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.01.2018
• Subjects: Biomarkers; Crohn's disease; Diagnosis; Disease; disease activity; Dysbacteriosis; Fecal microflora; Feces; Firmicutes; Gastroenterology; Geography; gut microbiota; Health care; Hospitals; Host-Microbe Biology; Immunotherapy; Inflammatory bowel disease; Inflammatory bowel diseases; Infliximab; infliximab treatment; Intestinal microflora; Intestine; Laboratories; Microbiomes; Microbiota; Minority & ethnic groups; Monoclonal antibodies; Multiculturalism & pluralism; Noninvasive evaluation; Pathogenesis; Research Article; Studies; TNF inhibitors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Ulcerative colitis; Beijing China; La Jolla California; California; United States > US; China; disease activity; infliximab treatment; gut microbiota; inflammatory bowel disease

In the present report, we show that the human fecal microbiota contains promising and universal biomarkers for the noninvasive evaluation of inflammatory bowel disease severity and IFX treatment efficacy, emphasizing the potential ability to mine the gut microbiota as a modality to stratify IBD pati...