Epstein-Barr Virus-Positive Cancers Show Altered B-Cell Clonality

• Published in: mSystems Vol. 3; no. 5
• Main Authors: Selitsky, Sara R., Marron, David, Mose, Lisle E., Parker, Joel S., Dittmer, Dirk P.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.09.2018
• Subjects: Acquired immune deficiency syndrome; Adenocarcinoma; AIDS; B cells; B-cell receptor; cancer; Cell proliferation; Clinical Science and Epidemiology; Deoxyribonucleic acid; DNA; EBV; Epithelial cells; Epstein-Barr virus; Gastric cancer; Gene expression; Genomes; Immune status; Infections; Lymphocytes B; Lymphoma; Metastases; Nasopharyngeal carcinoma; Research Article; TCGA; Throat cancer; Transcription; Tumors; virology; Viruses; North Carolina; United States > US; virology; herpesvirus; EBV; Epstein-Barr virus; cancer; B cells; TCGA
• ISSN: 2379-5077; 2379-5077
• DOI: 10.1128/msystems.00081-18

Around 20% of human cancers are associated with viruses. Epstein-Barr virus (EBV) contributes to gastric cancer, nasopharyngeal carcinoma, and certain lymphomas, but its role in other cancer types remains controversial. We assessed the prevalence of EBV in RNA-seq from 32 tumor types in the Cancer G...